Three-dose vaccination elicits neutralising antibodies against omicron

Mary Wu¹, Emma C Wall², Edward J Carr¹, Ruth Harvey³, Hermaleigh Townsley², Harriet V Mears¹, Lorin Adams³, Svend Kjaer¹, Gavin Kelly¹, Scott Warchal¹, Chelsea Sawyer¹, Caitlin Kavanagh¹, Christophe J Queval¹, Yenting Ngai⁴, Emine Hatipoglu⁴, Karen Ambrose¹, Steve Hindmarsh¹, Rupert Beale⁵, Steve Gamblin¹, Michael Howell¹, George Kassiotis⁶, Vincenzo Libri⁷, Bryan Williams⁷, Sonia Gandhi⁵, Charles Swanton⁵, David Lv Bauer⁸

Affiliations

¹ The Francis Crick Institute, London NW1 1AT, UK.
² The Francis Crick Institute, London NW1 1AT, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre and NIHR UCLH Clinical Research Facility, London, UK.
³ Worldwide Influenza Centre, The Francis Crick Institute, London, UK.
⁴ University College London, London, UK.
⁵ The Francis Crick Institute, London NW1 1AT, UK; University College London, London, UK.
⁶ The Francis Crick Institute, London NW1 1AT, UK; Department of Infectious Disease, St Mary's Hospital, Imperial College London, London, UK.
⁷ National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre and NIHR UCLH Clinical Research Facility, London, UK; University College London, London, UK.
⁸ The Francis Crick Institute, London NW1 1AT, UK. Electronic address: david.bauer@crick.ac.uk.

PMID: 35065005
PMCID: PMC8769665
DOI: 10.1016/S0140-6736(22)00092-7

Three-dose vaccination elicits neutralising antibodies against omicron

Mary Wu et al. Lancet. 2022.

. 2022 Feb 19;399(10326):715-717.

doi: 10.1016/S0140-6736(22)00092-7. Epub 2022 Jan 19.

Authors

Affiliations

¹ The Francis Crick Institute, London NW1 1AT, UK.
² The Francis Crick Institute, London NW1 1AT, UK; National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre and NIHR UCLH Clinical Research Facility, London, UK.
³ Worldwide Influenza Centre, The Francis Crick Institute, London, UK.
⁴ University College London, London, UK.
⁵ The Francis Crick Institute, London NW1 1AT, UK; University College London, London, UK.
⁶ The Francis Crick Institute, London NW1 1AT, UK; Department of Infectious Disease, St Mary's Hospital, Imperial College London, London, UK.
⁷ National Institute for Health Research (NIHR) University College London Hospitals (UCLH) Biomedical Research Centre and NIHR UCLH Clinical Research Facility, London, UK; University College London, London, UK.
⁸ The Francis Crick Institute, London NW1 1AT, UK. Electronic address: david.bauer@crick.ac.uk.

PMID: 35065005
PMCID: PMC8769665
DOI: 10.1016/S0140-6736(22)00092-7

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References

1. Wall EC, Wu M, Harvey R, et al. Neutralising antibody activity against SARS-CoV-2 VOCs B.1.617.2 and B.1.351 by BNT162b2 vaccination. Lancet. 2021;397:2331–2333. - PMC - PubMed
1. Wall EC, Wu M, Harvey R, et al. AZD1222-induced neutralising antibody activity against SARS-CoV-2 Delta VOC. Lancet. 2021;398:207–208. - PMC - PubMed
1. Cromer D, Steain M, Reynaldi A, et al. Neutralising antibody titres as predictors of protection against SARS-CoV-2 variants and the impact of boosting: a meta-analysis. Lancet Microbe. 2021;3:E52–E61. - PMC - PubMed
1. Medicines & Healthcare products Regulatory Agency Summary of product characteristics for Xevudy. Dec 2, 2021. https://www.gov.uk/government/publications/regulatory-approval-of-xevudy...
1. Dejnirattisai W, Shaw RH, Supasa P, et al. Reduced neutralisation of SARS-CoV-2 omicron B.1.1.529 variant by post-immunisation serum. Lancet. 2021;399:234–236. - PMC - PubMed

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Three-dose vaccination elicits neutralising antibodies against omicron

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Three-dose vaccination elicits neutralising antibodies against omicron

Authors

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Medical