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. 2022 Mar:116:319-327.
doi: 10.1016/j.ijid.2022.01.016. Epub 2022 Jan 19.

Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry

Daniella Nunes Pereira  1 , Leticia Ferreira Gontijo Silveira  2 , Milena Maria Moreira Guimarães  3 , Carísi Anne Polanczyk  4 , Aline Gabrielle Sousa Nunes  5 , André Soares de Moura Costa  6 , Barbara Lopes Farace  7 , Christiane Corrêa Rodrigues Cimini  8 , Cíntia Alcantara de Carvalho  9 , Daniela Ponce  10 , Eliane Würdig Roesch  11 , Euler Roberto Fernandes Manenti  12 , Fernanda Barbosa Lucas  13 , Fernanda d'Athayde Rodrigues  14 , Fernando Anschau  15 , Fernando Graça Aranha  16 , Frederico Bartolazzi  17 , Giovanna Grunewald Vietta  18 , Guilherme Fagundes Nascimento  19 , Helena Duani  20 , Heloisa Reniers Vianna  21 , Henrique Cerqueira Guimarães  22 , Jamille Hemétrio Salles Martins Costa  23 , Joanna d'Arc Lyra Batista  24 , Joice Coutinho de Alvarenga  25 , José Miguel Chatkin  26 , Júlia Drumond Parreiras de Morais  27 , Juliana Machado-Rugolo  28 , Karen Brasil Ruschel  29 , Lílian Santos Pinheiro  30 , Luanna Silva Monteiro Menezes  31 , Luciana Siuves Ferreira Couto  32 , Luciane Kopittke  33 , Luís César de Castro  34 , Luiz Antônio Nasi  35 , Máderson Alvares de Souza Cabral  36 , Maiara Anschau Floriani  37 , Maíra Dias Souza  38 , Marcelo Carneiro  39 , Maria Aparecida Camargos Bicalho  40 , Mariana Frizzo de Godoy  41 , Matheus Carvalho Alves Nogueira  42 , Milton Henriques Guimarães Júnior  43 , Natália da Cunha Severino Sampaio  44 , Neimy Ramos de Oliveira  45 , Pedro Ledic Assaf  46 , Renan Goulart Finger  47 , Roberta Xavier Campos  48 , Rochele Mosmann Menezes  49 , Saionara Cristina Francisco  50 , Samuel Penchel Alvarenga  51 , Silvana Mangeon Mereilles Guimarães  52 , Silvia Ferreira Araújo  53 , Talita Fischer Oliveira  54 , Thulio Henrique Oliveira Diniz  55 , Yuri Carlotto Ramires  56 , Evelin Paola de Almeida Cenci  57 , Thainara Conceição de Oliveira  58 , Alexandre Vargas Schwarzbold  59 , Patricia Klarmann Ziegelmann  60 , Roberta Pozza  61 , Caroline Scherer Carvalho  62 , Magda Carvalho Pires  63 , Milena Soriano Marcolino  64
Affiliations

Hypothyroidism does not lead to worse prognosis in COVID-19: findings from the Brazilian COVID-19 registry

Daniella Nunes Pereira et al. Int J Infect Dis. 2022 Mar.

Abstract

Background: It is not clear whether previous thyroid diseases influence the course and outcomes of COVID-19.

Methods: The study is a part of a multicentric cohort of patients with confirmed COVID-19 diagnosis from 37 hospitals. Matching for age, sex, number of comorbidities, and hospital was performed for the paired analysis.

Results: Of 7,762 patients with COVID-19, 526 had previously diagnosed hypothyroidism and 526 were matched controls. The median age was 70 years, and 68.3% were females. The prevalence of comorbidities was similar, except for coronary and chronic kidney diseases that were higher in the hypothyroidism group (p=0.015 and p=0.001). D-dimer levels were lower in patients with hypothyroid (p=0.037). In-hospital management was similar, but hospital length-of-stay (p=0.029) and mechanical ventilation requirement (p=0.006) were lower for patients with hypothyroidism. There was a trend of lower in-hospital mortality in patients with hypothyroidism (22.1% vs 27.0%; p=0.062).

Conclusion: Patients with hypothyroidism had a lower requirement of mechanical ventilation and showed a trend of lower in-hospital mortality. Therefore, hypothyroidism does not seem to be associated with a worse prognosis.

Keywords: COVID-19; Epidemiology; Hypothyroidism; Mortality; Prognosis.

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Figures

Fig 1
Fig. 1
Flowchart of patients included in the study.
See this image and copyright information in PMC

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