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Review
. 2022 Apr 1;29(2):131-140.
doi: 10.1097/MED.0000000000000715.

Hypertriglyceridemia: rationale, design and implementation of the Australian Hypertriglyceridemia Registry

Jing Pang  1 , Stephen C H Li  2 , Dick C Chan  1 , David R Sullivan  3 , Ann-Marie Woodward  4 , Gerald F Watts  1   4
Affiliations
Review

Hypertriglyceridemia: rationale, design and implementation of the Australian Hypertriglyceridemia Registry

Jing Pang et al. Curr Opin Endocrinol Diabetes Obes. .

Abstract

Purpose of review: Hypertriglyceridemia (HTG) is a risk factor for atherosclerotic cardiovascular disease (ASCVD), aortic stenosis, hepatic steatosis and pancreatitis. We briefly review the aetiology and treatment of HTG and familial chylomicronemia syndrome (FCS), as well as the implementation of a clinical quality registry for improving care, the Australian Hypertriglyceridemia (AUSTRIG) Registry.

Recent findings: There is a need to improve the detection of individuals with severe HTG and FCS, who could benefit from more intense and novel treatments to prevent end-organ damage. Patient registries provide valuable data for advancing care of individuals with severe HTG at high risk of acute pancreatitis, steatohepatitis and ASCVD. However, there is a paucity of registries of such patients. We outline the design and implementation of the AUSTRIG Registry.

Summary: Clinical registries can be employed in many ways for improving outcomes for patients with HTG, through the collation and analysis of data for enabling health service planning, clinical trials and audits, and for better informing and empowering registrants.

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References

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    1. Ginsberg HN, Packard CJ, Chapman MJ, et al. Triglyceride-rich lipoproteins and their remnants: metabolic insights, role in atherosclerotic cardiovascular disease, and emerging therapeutic strategies—a consensus statement from the European Atherosclerosis Society. Eur Heart J 2021; 42:4791–4806.
    1. Kaltoft M, Langsted A, Nordestgaard BG. Triglycerides and remnant cholesterol associated with risk of aortic valve stenosis: Mendelian randomization in the Copenhagen General Population Study. Eur Heart J 2020; 41:2288–2299.
    1. Pedersen SB, Langsted A, Nordestgaard BG. Nonfasting mild-to-moderate hypertriglyceridemia and risk of acute pancreatitis. JAMA Intern Med 2016; 176:1834–1842.
    1. Nordestgaard BG, Varbo A. Triglycerides and cardiovascular disease. Lancet 2014; 384:626–635.

Publication types

Supplementary concepts