Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Mar;40(3):841-847.
doi: 10.1007/s00345-021-03909-w. Epub 2022 Jan 23.

Impact of retrograde intrarenal surgery on biomarkers that are associated with renal parenchyma injury, a preliminary study

Lara Stächele  1   2 , Daniel J Stekhoven  3   4   5 , Jan A Birzele  6 , Martin Risch  7 , Räto T Strebel  6
Affiliations

Impact of retrograde intrarenal surgery on biomarkers that are associated with renal parenchyma injury, a preliminary study

Lara Stächele et al. World J Urol. 2022 Mar.

Abstract

Purpose: The primary objective of this preliminary study was to assess the changes in concentration of biomarkers, which indicate renal injury, after RIRS.

Materials and methods: Within this prospective study, we included 21 patients with nephrolithiasis requiring treatment with RIRS. From each patient, blood and urine samples were taken at fixed intervals before and after RIRS. Kidney injury molecule-1 (KIM-1), monocyte chemoattractant protein 1 (MCP-1), neutrophil gelatinase-associated lipocalin (NGAL), interleukin-18 (IL-18), calbindin, albumin, clusterin, gluthation S-transferase-π (GST-π), beta-2-microglobulin (B2M), osteopontin, cystatin c, and trefoil-factor-3 (TFF3) were measured in urine. Creatinine, cystatin c and uric acid were analyzed in the blood samples.

Results: A significant increase of the biomarkers clusterin, GST-π, B2M, NGAL and cystatin c was observed after RIRS. However, the biomarkers gradually normalized during the first 14 postoperative days. The parameters surgery time, cumulative stone volume, and BMI did not significantly influence the biomarker concentrations. In the case of GST-π and NGAL a significant positive, yet minuscule effect of age was observed.

Conclusions: With our study, we identified 5 out of 12 assessed renal injury biomarkers that showed a significant increase after RIRS. The increase was only temporary and all markers normalized within 14 days. Further studies are needed to determine the clinical value of these identified markers to assess the long-term impact of intrarenal pressure elevation during RIRS.

Keywords: Beta-2-microglobulin; Biomarkers; Clusterin; Cystatin C; Glutathione S-transferase-π; Neutrophil gelatinase-associated lipocalin; Predictors; Renal parenchyma injury; Retrograde intrarenal surgery.

PubMed Disclaimer

References

    1. Geraghty RM, Jones P, Somani BK (2017) Worldwide trends of urinary stone disease treatment over the last two decades: a systematic review. J Endourol 31:547–556 - PubMed
    1. de la Rosette J, Denstedt J, Geavlete P et al (2014) The clinical research office of the endourological society ureteroscopy global study: indications, complications, and outcomes in 11,885 patients. J Endourol 28:131–139 - PubMed
    1. Schuster TG, Hollenbeck BK, Faerber GJ et al (2001) Complications of ureteroscopy: analysis of predictive factors. J Urol 166:538–540 - PubMed
    1. Sofer M, Watterson JD, Wollin TA et al (2002) Holmium: YAG laser lithotripsy for upper urinary tract calculi in 598 patients. J Urol 167:31–34 - PubMed
    1. Winship B, Wollin D, Carlos E et al (2019) The rise and fall of high temperatures during ureteroscopic holmium laser lithotripsy. J Endourol 33:794–799 - PubMed

LinkOut - more resources