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. 2022 May;49(5):506-517.
doi: 10.1111/jcpe.13595. Epub 2022 Feb 27.

A common oral pathogen Porphyromonas gingivalis induces myocarditis in rats

Daniele Peron  1 , Renato Araujo Prates  1 , Ednei Luiz Antonio  2 , Ighor Luiz Azevedo Teixeira  2 , Helenita Antonia de Oliveira  2 , Barbara Sampaio Dias Martins Mansano  1 , Alexandre Bergamo  1 , Dirceu Rodrigues Almeida  2 , Rafael Dariolli  3   4 , Paulo José Ferreira Tucci  2 , Andrey Jorge Serra  2
Affiliations

A common oral pathogen Porphyromonas gingivalis induces myocarditis in rats

Daniele Peron et al. J Clin Periodontol. 2022 May.

Abstract

Aim: To evaluate whether Porphyromonas gingivalis (P. gingivalis) inoculation could induce cardiac remodelling in rats.

Materials and methods: The study was conducted on 33 Wistar rats, which were distributed in the following experimental groups: not inoculated; inoculated with 1 × 108 CFU/ml of bacteria; inoculated with 3 × 108 CFU/ml of bacteria. The animals were inoculated at baseline and on the 15th day of follow-up. Blood collection was performed at baseline and 60 min after each inoculation. At 29 days, the animals were subjected to echocardiography and at 30 days to haemodynamic studies before sacrificing them.

Results: Impact of the bacteria was more evident in rats that received higher P. gingivalis concentration. Thus, 3 × 108 CFU/ml of bacteria increased the rectal temperature and water content in the lung as well as myocardial necrosis and fibrosis. P. gingivalis induced the intensification of DNA fragmentation and increased the levels of malondialdehyde, oxidized proteins, and macrophage expression in the myocardium. These findings were associated with lower LV isovolumetric relaxation time, +dP/dt, -dP/dt, and higher end-diastolic pressure.

Conclusions: P. gingivalis bacteraemia is significantly associated with adverse cardiac remodelling and may play a biological role in the genesis of heart failure.

Keywords: Porphyromonas gingivalis; cardiovascular diseases; heart; inflammation.

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