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Review
. 2022 Mar;54(3):296-298.
doi: 10.1016/j.dld.2022.01.001. Epub 2022 Jan 12.

Liver histopathological changes and COVID-19: What does literature have to tell us?

Jorge Lucas de Sousa Moreira  1 , Sarah Maria Bacurau Barbosa  1 , Jacyanne Gino Vieira  1 , Nicolly Castelo Branco Chaves  1 , Jucier Gonçalves Júnior  2
Affiliations
Review

Liver histopathological changes and COVID-19: What does literature have to tell us?

Jorge Lucas de Sousa Moreira et al. Dig Liver Dis. 2022 Mar.
No abstract available

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Figures

Fig. 1
Fig. 1
[Adapted] A. Macrovesicular and microvesicular steatoses are demonstrated with platelet-fibrin thrombi are present in the sinusoidal spaces and central vein (H&E, ×400) . B. Ductular (black arrowhead) and canalicular (white arrowheads) cholestasis (H&E; scale bar 50µm) .
Fig. 2
Fig. 2
A: Example of genuine thrombosis: portal with clearly enlarged lumen obliterated by red cell mixed andstratified with lymphocytes and granulocytes (H&E,100 ×); B: smooth musde layer of portal vein lamina media extremely irregular fragmented (SMA, 100 ×); SAR-CoV-2 virions are demonstrated within vessel lumen and onendothelial cells (ISH) (inset); C: medium layer of a portal vein, partially lost and infiltrated by inflammatory cellslymphocytes, also attaching endothelial layer (AMA, 400×); CD3-positive lymphocytes attack endotelium andmedium vessel layer (inset); D: severe confluent haemorrhagic necrosis in a patient with elevation of ALT> 10 N(H&E, 100×); inset showing liver necrosis by apoptosis (H&E, 400×) [Adapted] .
See this image and copyright information in PMC

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References

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