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Multicenter Study
. 2022 Aug 1;49(8):e87-e89.
doi: 10.1097/OLQ.0000000000001605. Epub 2022 Jan 24.

Coinfection With Chlamydial and Gonorrheal Infection Among US Adults With Early Syphilis

Jodie Dionne-Odom  1 , Kimberly Workowski  2 , Charlotte Perlowski  3 , Stephanie N Taylor  4 , Kenneth H Mayer  5 , Candice J McNeil  6 , Matthew M Hamill  7 , Julia C Dombrowski  8 , Teresa A Batteiger  9 , Arlene C Sena  10 , Harold C Wiesenfeld  11 , Lori Newman  12 , Edward W Hook 3rd  1
Affiliations
Multicenter Study

Coinfection With Chlamydial and Gonorrheal Infection Among US Adults With Early Syphilis

Jodie Dionne-Odom et al. Sex Transm Dis. .

Abstract

Among 865 adults with early syphilis considered for a multicenter treatment trial, 234 (27%) were excluded before enrollment because of bacterial sexually transmitted infection coinfection. Coinfection with Neisseria gonorrhoeae (29%), Chlamydia trachomatis (22%), or both (23%) was common. Study findings highlight the need for comprehensive bacterial sexually transmitted infection screening in patients with syphilis.

Trial registration: ClinicalTrials.gov NCT03637660.

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Conflict of interest statement

Conflict of Interest and Sources of Funding: The authors declare no conflict of interest.

Figures

Figure 1:
Figure 1:. Flow Diagram
*STI coinfection type specified in Figure 2
Figure 2:
Figure 2:. Bacterial STI Coinfection Type among Adults with Early Syphilis * (n=234)
*These adults were found to be ineligible to participate in a syphilis treatment trial due to STI during the pre-screening process. The unspecified category was used between 09/12/2018 – 02/25/2019 and then STI type was specified between 02/26/19 – 08/27/21. CT = Chlamydia trachomatis; NG = Neisseria gonorrhoeae; Other = non-gonococcal urethritis (NGU) (6), lymphogranuloma venereum (LGV) (2).
See this image and copyright information in PMC

References

    1. Centers for Disease Control and Prevention. Sexually Transmitted Disease Surveillance 2019. 2021.
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    1. Centers for Disease Control and Prevention. STI Treatment Guidelines, 2021. 2021.
    1. de Voux A, Bernstein KT, Kirkcaldy RD, et al. Self-Reported Extragenital Chlamydia and Gonorrhea Testing in the Past 12 Months Among Men Who Have Sex with Men in the United States-American Men’s Internet Survey, 2017. Sex Transm Dis. 2019;46(9):563–570. - PMC - PubMed

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