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Review
. 2022 Jan;38(1):13-20.
doi: 10.6515/ACS.202201_38(1).20210830A.

Bone Marrow Origin of Coronary Artery Diseases: The Impact of the Local Renin-Angiotensin System

Ugur Nadir Karakulak  1 , Elifcan Aladag  2 , Ibrahim Celalettin Haznedaroğlu  2
Affiliations
Review

Bone Marrow Origin of Coronary Artery Diseases: The Impact of the Local Renin-Angiotensin System

Ugur Nadir Karakulak et al. Acta Cardiol Sin. 2022 Jan.

Abstract

The renin-angiotensin system (RAS) has both important systemic circulatory and local effects. The effects of local cardiac RAS on the cardiovascular system have been increasingly researched. In this study, we review the relationship between local bone marrow and local cardiac RAS and their impacts on atherosclerosis.

Keywords: Bone marrow; Coronary artery disease; Renin-angiotensin system.

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Figures

Figure 1
Figure 1
Possible functions of hematopoietic stem cells in the vasculature and cardiac microenviroment, suggesting the interrelationships of local bone marrow renin-angiotensin system (RAS), circulating RAS and local myocardial RAS. ACE, angiotensin coverting enzyme; Ang, angiotensin; AT1, angiotensin receptor 1; HSC, hematopoetic stem cell. Reprinted with permission from Hindawi https://www.hindawi.com/copyright/.
See this image and copyright information in PMC

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