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Review
. 2021 Dec 20;13(12):e20532.
doi: 10.7759/cureus.20532. eCollection 2021 Dec.

Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis

Dhan B Shrestha  1 , Pravash Budhathoki  2 , Prarthana Subedi  3 , Manita Khadka  3 , Prabesh Karki  3 , Yub Raj Sedhai  4 , Bhesh Raj Karki  5 , Wasey Ali Yadullahi Mir  1
Affiliations
Review

Acotiamide and Functional Dyspepsia: A Systematic Review and Meta-Analysis

Dhan B Shrestha et al. Cureus. .

Abstract

Functional dyspepsia is a common gastrointestinal disorder characterized by postprandial fullness or early satiety and epigastric burning or pain in the absence of organic disease. Acotiamide is a novel prokinetic motility drug being used in functional dyspepsia. Databases like PubMed, PubMed Central, Embase, and Scopus were searched for studies comparing the use of acotiamide and placebo for people with functional dyspepsia. Quantitative synthesis was performed using RevMan 5.4 (Cochrane, London, United Kingdom). The improvement in symptoms of functional dyspepsia after treatment was higher in people treated with acotiamide than placebo, although not statistically significant (OR, 1.48; 95% CI, 0.93 to 2.35; n = 1697; I2 = 59%). Among the commonly reported adverse effects, namely, raised in serum prolactin (OR 1.02, 95% CI 0.64 to 1.61; n = 1709; I2 = 44%), raised in alanine transaminase (OR 1.27, 95% CI 0.70 to 2.33; n = 1709; I2 = 0%), and raised in serum bilirubin (OR, 0.98; 95% CI, 0.52 to 1.87; I2 = 0%) did not differ between two groups. Acotiamide seems to be a promising agent in functional dyspepsia. However, further larger studies are needed to evaluate the role of acotiamide in functional dyspepsia.

Keywords: acotiamide; epigastric pain; functional dyspepsia; meta-analysis; prolactin.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Risk of-bias-assessment
Bias summary of five included studies [6-10]
Figure 2
Figure 2. PRISMA flow diagram
Figure 3
Figure 3. Forest plot showing improvement in symptoms of functional dyspepsia using a random-effect model
Only three studies reported symptomatic improvement [7,9,10].
Figure 4
Figure 4. Forest plot showing adverse laboratory parameters using fixed effect model
Only three studies reported adverse laboratory outcomes [7,9,10].
See this image and copyright information in PMC

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