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Review
. 2022 Feb;12(2):41.
doi: 10.1007/s13205-021-03105-y. Epub 2022 Jan 10.

Emerging uses of PLA-PEG copolymer in cancer drug delivery

Rohit Mundel #  1 , Tanya Thakur #  1 , Mary Chatterjee  1
Affiliations
Review

Emerging uses of PLA-PEG copolymer in cancer drug delivery

Rohit Mundel et al. 3 Biotech. 2022 Feb.

Abstract

Traditional therapies need high systematic dosages that not only destroys cancerous cells but also healthy cells. To overcome this problem recent advancement in nanotechnology specifically in nanomaterials has been extensively done for various biological applications, such as targeted drug delivery. Nanotechnology, as a frontier science, has the potential to break down all the obstacles to be more effective and secure drug delivery system. It is possible to develop nanopolymer based drug carrier that can target drugs with extreme accuracy. Polymers can advance drug delivery technologies by allowing controlled release of therapeutic drugs in stable amounts over long duration of time. For controlled drug delivery, biodegradable synthetic polymers have various benefits over non-biodegradable polymers. Biodegradable polymer either are less toxic or non-toxic. Polylactic Acid (PLA) is one of the most remarkable amphipathic polymers which make it one of the most suitable materials for polymeric micelles. Amphiphilic nanomaterial, such as Polyethylene Glycol (PEG), is one of the most promising carrier for tumor targeting. PLA-PEG as a copolymer has been generally utilized as drug delivery system for the various types of cancer. Chemotherapeutic drugs are stacked into PLA-PEG copolymer and as a result their duration time delays, hence medications arrive at specific tumor site.

Keywords: Cancer therapeutics; Carrier; Nanotechnology; Polymer; Targeted drug delivery.

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Conflict of interest statement

Conflict of interestOn behalf of all authors, the corresponding author states that there is no conflict of interest.

Figures

Fig. 1
Fig. 1
Route of Nanoparticle particularly at cancerous tissue
Fig. 2
Fig. 2
Different types of Nanocarriers used in drug delivery
Fig. 3
Fig. 3
Classification of different types of polymer
See this image and copyright information in PMC

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