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Review
. 2022 Jan 7:9:816266.
doi: 10.3389/fchem.2021.816266. eCollection 2021.

Facing Diseases Caused by Trypanosomatid Parasites: Rational Design of Pd and Pt Complexes With Bioactive Ligands

Dinorah Gambino  1 , Lucía Otero  1
Affiliations
Review

Facing Diseases Caused by Trypanosomatid Parasites: Rational Design of Pd and Pt Complexes With Bioactive Ligands

Dinorah Gambino et al. Front Chem. .

Abstract

Human African Trypanosomiasis (HAT), Chagas disease or American Trypanosomiasis (CD), and leishmaniases are protozoan infections produced by trypanosomatid parasites belonging to the kinetoplastid order and they constitute an urgent global health problem. In fact, there is an urgent need of more efficient and less toxic chemotherapy for these diseases. Medicinal inorganic chemistry currently offers an attractive option for the rational design of new drugs and, in particular, antiparasitic ones. In this sense, one of the main strategies for the design of metal-based antiparasitic compounds has been the coordination of an organic ligand with known or potential biological activity, to a metal centre or an organometallic core. Classical metal coordination complexes or organometallic compounds could be designed as multifunctional agents joining, in a single molecule, different chemical species that could affect different parasitic targets. This review is focused on the rational design of palladium(II) and platinum(II) compounds with bioactive ligands as prospective drugs against trypanosomatid parasites that has been conducted by our group during the last 20 years.

Keywords: antiparasitic agents; palladium; platinum; rational design; trypanosomatid parasites.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
Structure of Nifurtimox and Benznidazole.
FIGURE 2
FIGURE 2
Some current drugs for the treatment of Leishmaniasis.
FIGURE 3
FIGURE 3
Drugs for the treatment of HAT.
FIGURE 4
FIGURE 4
Bioactive 5-nitrofuryl-containing thiosemicarbazones (HTS) and their Pt(II) and Pd(II) complexes.
FIGURE 5
FIGURE 5
Bioactive thiosemicarbazones derived from 1-indanones (HIn) and their Pt(II) and Pd(II) complexes.
FIGURE 6
FIGURE 6
pyridine-2-thiol N-oxide (Hmpo) and their Pt(II) and Pd(II) complexes.
FIGURE 7
FIGURE 7
Trypanocidal 3-aminoquinoxaline-2- carbonitrile 1,4-dioxides (quino) and their Pd(II) complexes.
FIGURE 8
FIGURE 8
Pamidronate (pam) and alendronate (ale) mixed-ligand Pd(II) compounds.
FIGURE 9
FIGURE 9
(A) ferrocene moiety; (B) ferrocifen (C) ferroquine (D) 1,1'-bis(dipheny1phosphino) ferrocene, dppf.
FIGURE 10
FIGURE 10
Pd(II) and Pt(II) dppf compounds with selected bioactive ligands L, [M(dppf)(L)](PF6).
FIGURE 11
FIGURE 11
Structure of [M(dppf)(mpo)] (PF6) compounds, where M = Pd or Pt, mpo = pyridine-2-thiolato-1-oxide.
See this image and copyright information in PMC

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