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Meta-Analysis
. 2022 Sep;54(9):2227-2237.
doi: 10.1007/s11255-022-03125-4. Epub 2022 Jan 24.

Hyperuricemia aggravates the progression of IgA nephropathy

Yin-Hong Geng  1 , Zhe Zhang  1 , Jun-Jun Zhang  1 , Bo Huang  1 , Zui-Shuang Guo  1 , Xu-Tong Wang  1 , Lin-Qi Zhang  2 , Song-Xia Quan  1 , Rui-Min Hu  1 , Ya-Fei Liu  3
Affiliations
Meta-Analysis

Hyperuricemia aggravates the progression of IgA nephropathy

Yin-Hong Geng et al. Int Urol Nephrol. 2022 Sep.

Abstract

Objective: The relationship between hyperuricemia and IgA nephropathy (IgAN) was evaluated systematically in this research.

Methods: The Preferred Reporting Items for Systematic Review and Meta-analysis statement was employed to design and report the study.

Results: Twenty-five studies were included in this meta-analysis with a total of 6048 IgAN patients. The clinical indicators indicated that blood urea nitrogen (BUN) (p < 0.00001, mean difference (MD) = 2.60, 95% confidence interval (CI) 1.74-3.46), serum creatinine (Scr) (p < 0.00001, MD = 44.56, 95% CI 31.15-57.98), diastolic blood pressure(DBP) (p < 0.00001, MD = 3.86, 95% CI 2.84-4.88), systolic blood pressure(SBP) (p < 0.00001, MD = 6.71, 95% CI 4.70-8.71), and 24-h urine protein(24 h TP) (p < 0.00001, MD = 0.76, 95% CI 0.58-0.94) were significantly increased in IgAN with hyperuricemia group than that in normouricemic IgAN group. The pathological analysis indicated that mesangial proliferation (p < 0.00001, MD = 0.12, 95% CI 0.07-0.17), vascular lesion (p < 0.00001, MD = 0.17, 95% CI 0.13-0.20), segmental lesion (p < 0.00001, MD = 0.15, 95% CI 0.03-0.26), tubulointerstitial damage (p < 0.00001, MD = 1.27, 95% CI 1.06-1.48), and glomerulosclerosis (p < 0.00001, MD = 0.56, 95% CI 0.40-0.72) were considerably climbed in IgAN patients with hyperuricemia compared without hyperuricemia group. Additionally, the estimated glomerular filtration rate (p < 0.00001, MD = - 29.03, 95% CI - 36.83 to - 21.23) was decreased in IgAN patients with hyperuricemia compared with normouricemic group.

Conclusion: Hyperuricemia exacerbates IgAN prognosis through aggravating the clinical outcomes and pathological results of IgAN.

Keywords: Hyperuricemia; IgA nephropathy; Meta-analysis; Prognosis; Progression.

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References

    1. Zhou FD, Zhao MH, Zou WZ, Liu G, Wang H (2009) The changing spectrum of primary glomerular diseases within 15 years: a survey of 3331 patients in a single Chinese centre. Nephrol Dial Transpl 24(3):870–876. https://doi.org/10.1093/ndt/gfn554 - DOI
    1. Liu R, Han C, Wu D, Xia X, Gu J, Guan H et al (2015) Prevalence of hyperuricemia and gout in Mainland China from 2000 to 2014: a systematic review and meta-analysis. Biomed Res Int 2015:762820. https://doi.org/10.1155/2015/762820 - DOI - PubMed - PMC
    1. Liang MJ, Ou M, Chen XM, Zhang W, Chen W, Yang QQ et al (2013) Prevalence rate of hyperuricemia and its related risk factors in patients with IgA nephropathy. Chinese Journal of Nephrology 05:326–332
    1. Kang DH, Nakagawa T, Feng L, Watanabe S, Han L, Mazzali M et al (2002) A role for uric acid in the progression of renal disease. J Am Soc Nephrol 13(12):2888–2897. https://doi.org/10.1097/01.asn.0000034910.58454.fd - DOI - PubMed
    1. Sulikowska B, Manitius J et al (2007) Uric acid excretion and dopamine-induced glomerular filtration response in patients with Ig A glomerulonephritis. Am J Nephrol 28:391–396. https://doi.org/10.1159/000112271 - DOI - PubMed

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