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Editorial
. 2022 Mar 1;205(5):483-485.
doi: 10.1164/rccm.202112-2857ED.

COVID-19 Pathophysiology: An Opportunity to Start Appreciating Time-Dependent Variation

Lonneke A van Vught  1 , Lieuwe D J Bos  1
Affiliations
Editorial

COVID-19 Pathophysiology: An Opportunity to Start Appreciating Time-Dependent Variation

Lonneke A van Vught et al. Am J Respir Crit Care Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
Appreciation for time-dependent changes in coronavirus disease (COVID-19)–related severe acute respiratory failure. (A) Schematic of the biological situation as studied by Leisman and colleagues (3) in patients with COVID-19–related acute respiratory failure requiring ICU admission; these patients are characterized by alveolar epithelial injury, likely secondary to alveolar inflammation rather than systemic inflammation. (B) Illustration of the situation in these same patients after 3 days in the ICU; they have endothelial activation and injury, systemic inflammation, and thrombosis. (C) Schematic representation of the difference in information that can be obtained from one observation (squares) rather than multiple observations. The latter can be used to evaluate the dynamic changes over time and predict the future trajectory. Of note, the situation of biological signals is much more complex than for arrows (even though arrows have more complex trajectories than might be expected because of oscillations of the arrow itself, known as the archer’s paradox), and the provided cartoon should therefore not be interpreted such that precise prediction can be made with longitudinal measurements but just that accounting for time-related changes will likely better reflect reality than cross-sectional analyses.
See this image and copyright information in PMC

Comment on

  • Alveolar, Endothelial, and Organ Injury Marker Dynamics in Severe COVID-19.
    Leisman DE, Mehta A, Thompson BT, Charland NC, Gonye ALK, Gushterova I, Kays KR, Khanna HK, LaSalle TJ, Lavin-Parsons KM, Lilley BM, Lodenstein CL, Manakongtreecheep K, Margolin JD, McKaig BN, Rojas-Lopez M, Russo BC, Sharma N, Tantivit J, Thomas MF, Parry BA, Villani AC, Sade-Feldman M, Hacohen N, Filbin MR, Goldberg MB. Leisman DE, et al. Am J Respir Crit Care Med. 2022 Mar 1;205(5):507-519. doi: 10.1164/rccm.202106-1514OC. Am J Respir Crit Care Med. 2022. PMID: 34878969 Free PMC article.

References

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