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Review
. 2022 Feb:98:106234.
doi: 10.1016/j.ijsu.2022.106234. Epub 2022 Jan 21.

Current management of incidental gallbladder cancer: A review

Claudio F Feo  1 , Giorgio C Ginesu, Alessandro Fancellu, Teresa Perra, Chiara Ninniri, Giulia Deiana, Antonio M Scanu, Alberto Porcu
Affiliations
Free article
Review

Current management of incidental gallbladder cancer: A review

Claudio F Feo et al. Int J Surg. 2022 Feb.
Free article

Abstract

Early-stage gallbladder cancer (GBC) is mostly discovered incidentally by the pathologist after cholecystectomy for a presumed benign disease. It is the most common malignancy of the biliary tract with a variable incidence rate all over the World. The majority of patients with GBC remain asymptomatic for a long time and diagnosis is usually late when the disease is at an advanced stage. Radical surgery consisting in resection of the gallbladder liver bed and regional lymph nodes seems to be the best treatment option for incidental GBC. However, recurrence rates after salvage surgery are still high and the addition of neoadjuvant/adjuvant chemotherapy may improve outcomes. The aim of the present review is to evaluate current literature for advances in management of incidental GBC, with particular focus on staging techniques and surgical options.

Keywords: Gallbladder cancer; Incidental; Prognosis; Re-resection; Surgery.

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References

    1. Sharma A, Sharma KL, Gupta A, Yadav A, Kumar A. Gallbladder cancer epidemiology, pathogenesis and molecular genetics: recent update. World J. Gastroenterol . 2017;23:3978-3998. http://dx.doi.org/10.3748/wjg.v23.i22.3978 .
    1. Schmidt MA, Marcano-Bonilla L, Roberts LR. Gallbladder cancer: epidemiology and genetic risk associations. Chin. Clin. Oncol. 8, 2019, 31. http://dx.doi.org/10.21037/cco.2019.08.13
    1. Lau CSM, Zywot A, Mahendraraj K, Chamberlain RS. Gallbladder carcinoma in the United States: a population based clinical outcomes study involving 22,343 patients from the surveillance, epidemiology, and end result database (1973-2013). HPB Surg. 2017, 2017, 1532835. http://dx.doi.org/10.1155/2017/1532835
    1. Shukla SK, Singh G, Shahi KS, Bhuvan Pant P. Staging, treatment, and future approaches of gallbladder carcinoma. J. Gastrointest. Cancer . 2018;49:9-15. http://dx.doi.org/10.1007/s12029-017-0036-5 .
    1. Pitt SC, Jin LX, Hall BL, Strasberg SM, Pitt HA. Incidental gallbladder cancer at cholecystectomy: when should the surgeon be suspicious? Ann. Surg . 2014;260:128-133. http://dx.doi.org/10.1097/SLA.0000000000000485 .