Malignant pleural mesothelioma with an EML4-ALK fusion: Expect the unexpected!

Affiliations

¹ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
² Molecular Diagnostics Ghent University Hospital (MDG), Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Centre for Medical Genetics, Ghent University Hospital, Ghent University, Ghent, Belgium.
³ CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Centre for Medical Genetics, Ghent University Hospital, Ghent University, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
⁴ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
⁵ Department of Pathology, AZ St. Maarten, Mechelen, Belgium.
⁶ Department of Radiology, General Hospital Sint-Maarten Mechelen, Antwerp University Hospital, Antwerp University, Antwerp and Ghent University, Ghent, Belgium.
⁷ Department of Pneumology, General Hospital Sint-Maarten Mechelen, Antwerp University Hospital, Antwerp University, Belgium.
⁸ Department of Thoracic and Vascular Surgery, AZ Sint-Maarten Hospital, Mechelen, Belgium.
⁹ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium.
¹⁰ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.
¹¹ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium. Electronic address: david.creytens@uzgent.be.

PMID: 35074700
DOI: 10.1016/j.prp.2022.153772

Case Reports

Malignant pleural mesothelioma with an EML4-ALK fusion: Expect the unexpected!

Fleur Cordier et al. Pathol Res Pract. 2022 Mar.

. 2022 Mar:231:153772.

doi: 10.1016/j.prp.2022.153772. Epub 2022 Jan 19.

Authors

Affiliations

¹ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium.
² Molecular Diagnostics Ghent University Hospital (MDG), Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Centre for Medical Genetics, Ghent University Hospital, Ghent University, Ghent, Belgium.
³ CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Centre for Medical Genetics, Ghent University Hospital, Ghent University, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
⁴ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Department of Biomolecular Medicine, Ghent University, Ghent, Belgium.
⁵ Department of Pathology, AZ St. Maarten, Mechelen, Belgium.
⁶ Department of Radiology, General Hospital Sint-Maarten Mechelen, Antwerp University Hospital, Antwerp University, Antwerp and Ghent University, Ghent, Belgium.
⁷ Department of Pneumology, General Hospital Sint-Maarten Mechelen, Antwerp University Hospital, Antwerp University, Belgium.
⁸ Department of Thoracic and Vascular Surgery, AZ Sint-Maarten Hospital, Mechelen, Belgium.
⁹ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium; Faculty of Medicine and Health Sciences, Antwerp University, Wilrijk, Belgium.
¹⁰ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium.
¹¹ Department of Pathology, Ghent University Hospital, Ghent University, Ghent, Belgium; CRIG, Cancer Research Institute Ghent, Ghent University Hospital, Ghent University, Ghent, Belgium. Electronic address: david.creytens@uzgent.be.

PMID: 35074700
DOI: 10.1016/j.prp.2022.153772

Abstract

Case report of malignant pleural mesothelioma with an ALK gene rearrangement, detected by FISH and confirmed by RNA-based next-generation sequencing. The co-occurrence of ALK gene fusions with the more common genetic alterations in CDKN2A, NF2 and BAP1 has, to our best knowledge, not yet been described in malignant mesothelioma. Furthermore, this unexpected finding could suggest a potential target for therapy in this subset of malignant mesotheliomas.

Keywords: ALK fusion; Copy-number variation sequencing; Immunohistochemistry; Molecular techniques; Next-generation sequencing; Pleural mesothelioma.

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Malignant pleural mesothelioma with an EML4-ALK fusion: Expect the unexpected!

Affiliations

Malignant pleural mesothelioma with an EML4-ALK fusion: Expect the unexpected!

Authors

Affiliations

Abstract

Publication types

MeSH terms

Substances

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Miscellaneous