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Randomized Controlled Trial
. 2022 Jan 15:2022:3279503.
doi: 10.1155/2022/3279503. eCollection 2022.

Effect of Huaiqihuang Granules Combined with Comprehensive Nursing on Children with Primary Nephrotic Syndrome

Guiyun Yang  1 , Huanqin Yang  1 , Shifang Cui  2 , Jinling Shan  1
Affiliations
Randomized Controlled Trial

Effect of Huaiqihuang Granules Combined with Comprehensive Nursing on Children with Primary Nephrotic Syndrome

Guiyun Yang et al. J Healthc Eng. .

Abstract

Background: To observe the effect of Huaiqihuang granules combined with comprehensive nursing intervention on children with primary nephrotic syndrome (PNS) and its effect on renal function index.

Methods: A total of 104 patients were included, and the patients were randomly divided into two groups, with 52 cases in each group. The control group was treated with glucocorticoid, and the study group was treated with Huaiqihuang granules. The clinical efficacy of the two groups was observed. The levels of TG, TC, EGFR, 24 h UTP, BUN, Scr, IgA, IgG, IgM, IFN-γ and TNF-α were compared between two groups before and after treatment. The incidence of adverse reactions and recurrence rate after treatment were compared between the two groups.

Results: The effective rate of the study group (94.23%) was significantly higher than that of the control group (78.85%). Before treatment, there was no significant difference in TG and TC levels between the two groups. After treatment, the levels of TG and TC in both groups were decreased, and the decrease was more obvious in the study group. Compared with before treatment, the levels of 24 h UTP, BUN, Scr, IFN-γ, and TNF-α in both groups were significantly decreased after treatment, while EGFR, IgA, IgG, and IgM levels were significantly increased. Compared with the control group, the changes of each index in the study group were more obvious after treatment. After treatment, the incidence of adverse reactions and recurrence rate in the study group were significantly lower than those in the control group.

Conclusions: Huaiqihuang granules combined with comprehensive nursing treatment in children with PNS can reduce the occurrence of recent recurrence and adverse reactions and improve the cellular immune function and renal function.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Figure 1
Figure 1
Comparison of blood lipid levels between the two groups before and after treatment. The comparison of (a) TG levels and (b) TC levels between the two groups at 30, 60, and 90 days before treatment.
Figure 2
Figure 2
Comparison of renal function levels between the two groups before and after treatment. The comparison of (a) EGFR levels, (b) 24 h UTP levels, (c) BUN levels, and (d) Scr levels between the two groups before and after treatment.
Figure 3
Figure 3
Comparison of immunoglobulins between the two groups before and after treatment. The comparison of (a) IgA levels, (b) IgG, and (c) IgM levels before treatment between the two groups.
Figure 4
Figure 4
Comparison of serum cytokines levels between the two groups before and after treatment. The comparison of (a) serum IFN-γ levels and (b) serum TNF-α levels between the two groups before and after treatment.
See this image and copyright information in PMC

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