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. 2022 Feb;28(2):436-439.
doi: 10.3201/eid2802.211270.

Zoonotic Infection with Oz Virus, a Novel Thogotovirus

Ngo T B Tran, Hiroshi Shimoda, Keita Ishijima, Kenzo Yonemitsu, Shohei Minami; Supriyono; Yudai Kuroda, Kango Tatemoto, Milagros V Mendoza, Ryusei Kuwata, Ai Takano, Masahiko Muto, Kyoko Sawabe, Haruhiko Isawa, Daisuke Hayasaka, Ken Maeda

Zoonotic Infection with Oz Virus, a Novel Thogotovirus

Ngo T B Tran et al. Emerg Infect Dis. 2022 Feb.

Abstract

Oz virus is a novel thogotovirus isolated from ticks that causes lethal infection in mice. We conducted serosurveillance of Oz virus infection among humans and wild mammals in Japan using virus-neutralization tests and ELISAs. Results showed that Oz virus may be naturally infecting humans and other mammalian hosts.

Keywords: Japan; Oz virus; arboviruses; thogotoviruses; tick-borne viruses; vector-borne infections; viruses; zoonoses.

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Figures

Figure 1
Figure 1
Dot plot comparison between VN test and ELISA against Oz virus in serum samples from wild animals in Yamguchi prefecture, Japan. A) Macaques (n = 40); B) wild boar (n = 124); C) sika deer (n = 76). The correlation coefficient between VN test and ELISA from macaques was 0.9163, from wild boars was 0.8807, and from sika deer was 0.7569. The optimal cutoff value of ELISA was calculated by 2-graph receiver-operating characteristic curve. The optimal cutoff values were set at 0.225 for macaques, 0.197 for wild boar, and 0.317 for sika deer serum samples and are indicated by dotted lines.
Figure 2
Figure 2
Collection sites of serum samples from macaques, wild boars, and sika deer for study of Oz virus seroprevalence in Japan. Gray shading indicates prefectures in which samples were collected; black shading indicates Ehime prefecture, where Oz virus was first isolated.
See this image and copyright information in PMC

References

    1. Hubálek Z, Rudolf I, Nowotny N. Arboviruses pathogenic for domestic and wild animals. Adv Virus Res. 2014;89:201–75. 10.1016/B978-0-12-800172-1.00005-7 - DOI - PubMed
    1. Contreras-Gutiérrez MA, Nunes MRT, Guzman H, Uribe S, Suaza Vasco JD, Cardoso JF, et al. Sinu virus, a novel and divergent orthomyxovirus related to members of the genus Thogotovirus isolated from mosquitoes in Colombia. [Erratum in: Virology. 2017;503:114.]. Virology. 2017;501:166–75. 10.1016/j.virol.2016.11.014 - DOI - PMC - PubMed
    1. Temmam S, Monteil-Bouchard S, Robert C, Baudoin JP, Sambou M, Aubadie-Ladrix M, et al. Characterization of viral communities of biting midges and identification of novel Thogotovirus species and Rhabdovirus genus. Viruses. 2016;8:77. 10.3390/v8030077 - DOI - PMC - PubMed
    1. Da Silva EV, Da Rosa AP, Nunes MR, Diniz JA, Tesh RB, Cruz AC, et al. Araguari virus, a new member of the family Orthomyxoviridae: serologic, ultrastructural, and molecular characterization. Am J Trop Med Hyg. 2005;73:1050–8. 10.4269/ajtmh.2005.73.1050 - DOI - PubMed
    1. Moore DL, Causey OR, Carey DE, Reddy S, Cooke AR, Akinkugbe FM, et al. Arthropod-borne viral infections of man in Nigeria, 1964-1970. Ann Trop Med Parasitol. 1975;69:49–64. 10.1080/00034983.1975.11686983 - DOI - PubMed

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