Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Postmortem Surveillance for Ebola Virus Using OraQuick Ebola Rapid Diagnostic Tests, Eastern Democratic Republic of the Congo, 2019-2020

Daniel Mukadi-Bamuleka et al. Emerg Infect Dis. 2022 Feb.

Abstract

After a pilot study, we tested 443 cadavers using OraQuick Ebola rapid diagnostic tests during surveillance after the 10th Ebola outbreak in the Democratic Republic of the Congo. No false negative and 2% false-positive results were reported. Quickly returning results and engaging the community enabled timely public health actions.

Keywords: Democratic Republic of the Congo; Ebola virus; OraQuik Ebola RDT; postmortem surveillance; rapid diagnostic test; viruses; zoonoses.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Beni Health zone with sites of Ebola virus disease sample collection for study on postmortem surveillance for Ebola virus using OraQuick (OraSure Technologies, Inc., https://www.orasure.com) Ebola rapid diagnostic tests, eastern Democratic Republic of the Congo, 2019–2020. The numbers and the geolocation rapid diagnostic testing are provided in heatmaps from blue (fewer cases) to red (most cases). Most of the cases were from the health care facilities in Beni township. Inset shows location of the Beni Health zone in the Democratic Republic of the Congo and in Africa.
Figure 2
Figure 2
Algorithm of Ebola virus disease RDT implementation in North Kivu in the Beni health zone during active transmission (active surveillance) and postepidemic enhanced surveillance (enhanced surveillance), Democratic Republic of the Congo, 2019–2020. This information was used to inform burial planning and SDBs when indicated. EVD, Ebola virus disease; RDT, rapid diagnostic test (OraQuick, OraSure Technologies, Inc., https://www.orasure.com); RT-PCR, reverse transcription PCR; SDBs, safe and dignified burials.
See this image and copyright information in PMC

References

    1. Christie A, Neatherlin JC, Nichol ST, Beach M, Redfield RR. Ebola response priorities in the time of covid-19. N Engl J Med. 2020;383:1202–4. 10.1056/NEJMp2025512 - DOI - PubMed
    1. World Health Organization. Ebola virus disease—Democratic Republic of the Congo: disease outbreak news: update 23 January 2020. [cited 2021 Apr 4]. https://wwwwhoint/csr/don/23-january-2020-ebola-drc
    1. Mbala-Kingebeni P, Pratt C, Mutafali-Ruffin M, Pauthner MG, Bile F, Nkuba-Ndaye A, et al. Ebola virus transmission initiated by relapse of systemic Ebola virus disease. N Engl J Med. 2021;384:1240–7. 10.1056/NEJMoa2024670 - DOI - PMC - PubMed
    1. Den Boon S, Marston BJ, Nyenswah TG, Jambai A, Barry M, Keita S, et al. Ebola virus infection associated with transmission from survivors. Emerg Infect Dis. 2019;25:249–55. 10.3201/eid2502.181011 - DOI - PMC - PubMed
    1. Vetter P, Fischer WA II, Schibler M, Jacobs M, Bausch DG, Kaiser L. Ebola virus shedding and transmission: review of current evidence. J Infect Dis. 2016;214(suppl 3):S177–84. 10.1093/infdis/jiw254 - DOI - PMC - PubMed