Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Feb 28;50(1):375-386.
doi: 10.1042/BST20210246.

Mechanism of action of nucleotide excision repair machinery

Areetha D'Souza  1 , Alexandra M Blee  1 , Walter J Chazin  1
Affiliations
Review

Mechanism of action of nucleotide excision repair machinery

Areetha D'Souza et al. Biochem Soc Trans. .

Abstract

Nucleotide excision repair (NER) is a versatile DNA repair pathway essential for the removal of a broad spectrum of structurally diverse DNA lesions arising from a variety of sources, including UV irradiation and environmental toxins. Although the core factors and basic stages involved in NER have been identified, the mechanisms of the NER machinery are not well understood. This review summarizes our current understanding of the mechanisms and order of assembly in the core global genome (GG-NER) pathway.

Keywords: DNA synthesis and repair; nucleotide excision repair; structural biology.

PubMed Disclaimer

Conflict of interest statement

Competing Interests

The authors declare that there are no competing interests associated with the manuscript.

Figures

Figure 1.
Figure 1.. The trajectory of dynamic assembly of the core GG-NER machinery.
Four steps are identified: (A) damage recognition, (B) damage verification, (C) pre-incision, and (D) dual incision.
Figure 2.
Figure 2.. Cryo-EM structures of TFIIH complexe.
(A) Yeast TFIIH and XPC-HR23B-Cen2. (B) Human TFIIH and XPA.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lindahl T and Wood RD, Quality control by DNA repair. Science, 1999. 286(5446): p. 1897–1905. - PubMed
    1. Cleaver J, Defective repair replication of DNA in xeroderma pigmentosum. nature, 1968. 218(5142): p. 652–656. - PubMed
    1. Marteijn JA, et al., Understanding nucleotide excision repair and its roles in cancer and ageing. Nature reviews Molecular cell biology, 2014. 15(7): p. 465–481. - PubMed
    1. Schärer OD, Nucleotide excision repair in eukaryotes. Cold Spring Harbor perspectives in biology, 2013. 5(10): p. a012609. - PMC - PubMed
    1. Tornaletti S and Hanawalt PC, Effect of DNA lesions on transcription elongation. Biochimie, 1999. 81(1-2): p. 139–146. - PubMed

Publication types