Epidural unilateral stimulation with "adaptive stim" option in treatment of type II CRPS

Abstract

CRPS is a type of severe pain syndrome and can be triggered by previous surgery or trauma. CRPS involves vasomotor changes such as changes in color and temperature of the skin, edema, increased sensitivity to touch, and a limited range of movement. Depending on the presence of nerve damage, CRPS is divided into two types. CRPS type II is associated with a confirmed peripheral nerve injury, while CRPS type I is not associated with an apparent peripheral nerve injury. Despite the ongoing therapy, sometimes, patients still have persistent, burning pain. Intractable CRPS that fail more conservative treatments may undergo neuromodulation. We want to present to your attention a case report of the successful treatment of a patient with CRPS type II using epidural unilateral stimulation. The 44-year-old woman came to us with complaints of burning pain and numbness of 1-3 fingers of the right hand, the lateral surface of the right wrist, and lower quarter of the forearm, and shooting pain in the projection of the right median nerve from the shoulder to the wrist. A clinical diagnosis was made-CRPS type II. During the stimulation trial, the most effective pain relief was obtained when the electrode was located in the right side of epidural space at the C4-Th1 level. The implantation of a pulse generator was performed, and the final selection of the stimulation parameters was carried out (Pulse width: 60 ms, Rate: 210 Hz, and Amplitude: 0.9-1.6 V). The severity of pain syndrome was measured using validated scales in the preoperative period (VAS: 8-9, Pain Detect: 22, NTSS-9: 4.62, and DN4: 8), in the early postoperative period (VAS: 0-1, Pain Detect: 6, NTSS -9: 0.66, and DN4: 1), and after 12 months (VAS: 0-2, Pain Detect: 6, NTSS-9: 0.99, and DN4: 1). Observation during 12 months showed that a stable analgesic effect of neurostimulation was achieved using standard neuromodulation regimens and the adaptive stim option. Unilateral stimulation is an effective type of SCS in the treatment of pain syndromes. adaptive stim is usually not applicable for lead implantation at the cervical level. Nevertheless, the rational use of stimulation at threshold values allowed our patient to use adaptive stim in a non-standard situation.

Keywords: CRPS; SCS; epidural stimulation; neuromodulation; type 2 CRPS.

FIGURE 1

(A) Electrode located in the right side of epidural space at the C4 ‐ Th1 level; (B) The impulse generator implanted and connected to the electrode