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Case Reports
. 2022 Jan 18;10(1):e05311.
doi: 10.1002/ccr3.5311. eCollection 2022 Jan.

Compound blue nevus: A misleading pigmented melanocytic tumor

Massara Baklouti  1 , Khadija Sellami  1 , Neila Elleuch  1 , Mariem Rekik  1 , Ines Saguem  2 , Chahir Kamoun  2 , Naourez Gouiaa  2 , Hela Ben Messaoud  3 , Fathi Karray  3 , Mohamed Abdelmoula  3 , Tahia Sellami  2 , Hamida Turki  1
Affiliations
Case Reports

Compound blue nevus: A misleading pigmented melanocytic tumor

Massara Baklouti et al. Clin Case Rep. .

Abstract

Compound blue nevus had clinical and histological similarities with other heavily pigmented melanocytic tumor, like the pigmented epithelioid melanocytoma. Distinctive genomic aberrations have allowed differentiating it. The defining characteristic of blue nevi family is the presence of activating mutations in the G protein α-subunits, GNAQ and GNA11.

Keywords: dermatology; genetics.

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Conflict of interest statement

The authors have no potential conflict of interest to disclose.

Figures

FIGURE 1
FIGURE 1
Solitary, well‐demarcated and symmetrical blue‐gray nodular lesion, measuring 15 mm in diameter
FIGURE 2
FIGURE 2
Dermoscopic findings: blue‐steel pigmentation with hypopigmented yellowish areas and linear irregular vessels
FIGURE 3
FIGURE 3
(A) Histology showing dermal proliferation of heavily pigmented epithelioid (HE× 400); (B) Spindle cells with an additional junctional dendritic component (arrow and inset; HE× 200)
See this image and copyright information in PMC

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