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. 2022 Jan 16:14:7-15.
doi: 10.2147/RRU.S346020. eCollection 2022.

Urinary Tract Infection in Hemodialysis-Dependent End-Stage Renal Disease Patients

Kaori Yamashita  1   2 , Yudai Ishiyama  1 , Maki Yoshino  1 , Hidekazu Tachibana  1 , Daisuke Toki  1 , Ryuichiro Konda  2 , Tunenori Kondo  1
Affiliations

Urinary Tract Infection in Hemodialysis-Dependent End-Stage Renal Disease Patients

Kaori Yamashita et al. Res Rep Urol. .

Abstract

Introduction: The aim of this study was to analyze urinalysis findings and urinary bacterial culture in hemodialysis-dependent end-stage renal disease patients. The research goal was to understand the proportion, risk factors, and the causative organisms of urinary tract infection in hemodialysis-dependent end-stage renal disease patients.

Materials and methods: Between May 2020 and June 2021, this study included 100 hemodialysis-dependent end-stage renal disease patients (50 male patients and 50 female patients). The urine underwent microscopic examination, pyuria was defined as ≥5 white blood cells per high-power field, and urinary bacterial cultures were conducted for patients with pyuria. Bacteriuria was defined as ≥104 colony-forming units/mL in men and ≥105 colony-forming units/mL in women. Daily urine output was investigated by oral listening. Postvoiding residual urine volume was measured.

Results: Fifty-six percent of male patients and 30% of female patients had normosthenuria, 24% of male patients and 38% of female patients had pyuria, and 20% of male patients and 32% of female patients had a urinary tract infection. A comparison of normosthenuria and urinary tract infection revealed no statistically significant difference in age, time on dialysis, daily urine output, and postvoiding residual urine volume. The proportion of female patients among those with normosthenuria was 34.8%, whereas the proportion of female patients among those with UTI was 61.5%. Urinary bacterial cultures showed that the major causative organisms were Escherichia coli (45%; 18/40 cultures) and extended spectrum beta-lactamase-producing Escherichia coli (17.5%; 7/40 cultures).

Conclusion: The incidence of urinary tract infection was higher in female patients than in male patients. The proportion of resistant bacteria as the causative organisms was high in hemodialysis-dependent end-stage renal disease patients. Urinary bacterial culture should be checked while patients are able to void urine.

Keywords: bacteriuria; pyuria; renal dialysis; urinary tract infection; urine.

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Conflict of interest statement

The authors have no conflicts of interest directly relevant to the content of this article.

Figures

Figure 1
Figure 1
The proportion of normosthenuria, pyuria, and urinary tract infection in hemodialysis-dependent end-stage renal disease patients.
Figure 2
Figure 2
The antimicrobial susceptibility of extended spectrum beta-lactamase-producing Escherichia coli was categorized as susceptible, intermediate, or resistant. Sixteen antibacterial drugs were tested with seven strains of extended spectrum beta-lactamase-producing Escherichia coli.
See this image and copyright information in PMC

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