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. 2022 Jan 19;3(1):e12654.
doi: 10.1002/emp2.12654. eCollection 2022 Feb.

Temporal trends in reperfusion therapy for patients with acute ischemic stroke

Carlos El Khoury  1   2 , Corine Aboa-Eboule  3 , Laurie Fraticelli  1   4 , Clément Claustre  1 , Magali Bischoff  1 , Karine Blanc-Lasserre  5 , Marielle Buisson  3 , Serkan Cakmak  6 , Tee-Hi Cho  7 , Bruno Ferroud-Plattet  1 , Olivier Guerrier  1 , Frédéric Philippeau  8 , Patrice Serre  1   9 , Laura Mechtouff  1 , Norbert Nighoghossian  7 , Thierry Ruzteroltz  1 , Anne-Evelyne Vallet  10 , Elodie Ong  1 , Laurent Derex  1 ; RESCUE‐RESUVal group
Affiliations

Temporal trends in reperfusion therapy for patients with acute ischemic stroke

Carlos El Khoury et al. J Am Coll Emerg Physicians Open. .

Abstract

Objectives: To analyze the temporal trends in thrombolysis rates after implementation of a regional emergency network for acute ischemic stroke (AIS).

Methods: We conducted a retrospective study based on a prospective multicenter observational registry. The AIS benefited from reperfusion therapy included in 1 of the 5 primary stroke units or 1 comprehensive stroke center and 37 emergency departments were included using a standardized case report form. The population covers 3 million inhabitants.

Results: In total, 32,319 AIS was reported in the regional hospitalization database of which 2215 thrombolyzed AIS patients were included in the registry and enrolled in this study. The annual incidence rate of thrombolysis continuously and significantly increased from 2010 to 2018 (10.2% to 17.3%, P-trend = 0.0013). The follow-up of the onset-to-door and the door-to-needle delays over the study period showed stable rates, as did the all-cause mortality rate at 3-months (13.2%).

Conclusion: Although access to stroke thrombolysis has increased linearly since 2010, the 3-month functional outcome has not evolved as favorably. Further efforts must focus on reducing hospital delays.

Keywords: acute ischemic stroke; evolution of professional practices; reperfusion therapy; temporal trend.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Annual incidence rate of AIS thrombolysis from October 2010 to September 2018. AIS, acute ischemic stroke
FIGURE 2
FIGURE 2
Comparison of the onset‐to‐door and the door‐to‐needle delays over the study period
FIGURE 3
FIGURE 3
Functional outcome (3‐month Rankin score) over the study period
See this image and copyright information in PMC

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