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. 1987 Feb;2(1):38-40.
doi: 10.1002/bmc.1130020111.

Determination of adriamycin and its fluorescent metabolites in human plasma by HPLC

R Mahdadi  1 , M Lhermitte, J J Lafitte
Affiliations

Determination of adriamycin and its fluorescent metabolites in human plasma by HPLC

R Mahdadi et al. Biomed Chromatogr. 1987 Feb.

Abstract

We describe a method for measuring adriamycin and its metabolites, adriamycinol and adriamycinone in plasma, using reversed phase HPLC and fluorescence detection. The lower limit of detection is approximately 1 ng/mL for each compound. An extraction technique for serum is described which is capable of an almost equal recovery (greater than 93%) of adriamycin and metabolites without interference from endogenous components of plasma and from other common drugs. Within-day and day to day coefficients of variation are estimated.

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