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. 2022 Nov;19(7):1901-1910.
doi: 10.1111/iwj.13760. Epub 2022 Jan 27.

Risks of ozonated oil and ozonated water on human skin: A systematic review

Brian R Leon  1 , Daniel J Romary  1 , Sarah A Landsberger  1 , K Nicole Bradner  2 , Mirian Ramirez  1 , Robert M Lubitz  1
Affiliations

Risks of ozonated oil and ozonated water on human skin: A systematic review

Brian R Leon et al. Int Wound J. 2022 Nov.

Abstract

Ozonated water and oil are emerging as potential dermatologic therapeutics, particularly for the treatment of various wounds. However, the safety of these liquids has not been extensively studied. The aim of this systematic review was to evaluate the risks of ozonated liquids to human skin tissue based on the available literature. We completed a structured search of five scientific databases and identified 378 articles for consideration. Based on pre-established inclusion/exclusion criteria, nine studies were included in this review. Two studies specifically evaluated the cytotoxicity of ozonated liquids on human cells, five studies evaluated ozonated liquids in randomised controlled trials (RCTs), one was a post-market surveillance study, and one was a crossover study in humans. None of the included studies found any significant human dermatologic risks associated with ozonated water or liquid. Because of the small sample size, however, additional short- and long-term RCTs specifically designed to evaluate the dermatological risks of ozonated liquids are recommended.

Keywords: dermatologic agent; drug-related side effects and adverse reactions; ozone; topical administration; wound healing.

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Conflict of interest statement

BRL, DJR, SAL, and KNB were compensated through an unrestricted grant from 3Oe Scientific, Inc. BRL also serves on the medical advisory board of and holds equity in 3Oe Scientific, Inc. RML is compensated by and holds equity in 3Oe Scientific, Inc.

Figures

FIGURE 1
FIGURE 1
PRISMA diagram for study selection
FIGURE 2
FIGURE 2
Risk of bias, assessed as low (L), high (H) or unclear (−)
See this image and copyright information in PMC

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