Comment
doi: 10.1084/jem.20212539.
Epub 2022 Jan 27.
Vascular heterogeneity: VEGF receptors make blood vessels special
Affiliations
- PMID: 35085381
- PMCID: PMC8932539
- DOI: 10.1084/jem.20212539
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Comment
Vascular heterogeneity: VEGF receptors make blood vessels special
J Exp Med.
.
Abstract
Karaman et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20210565) examined the differential effects of the conditional deletion of genes encoding each VEGF receptor, VEGFR1, VEGFR2 and VEGFR 3, as well as combinations thereof in mice. The results highlight the crosstalk between receptors in different organs and emphasize the importance of VEGF receptor expression and interplay in vascular heterogeneity.
© 2022 Li and Ferrara.
Figures
Insights from Pin Li and Napoleone Ferrara.
Heterogeneity in the vasculature allows different organs to fulfil distinct functions. There are several characteristics of organotypic vasculature, including specific transcriptional programs in differentiated EC; heterogeneity in EC based on the metabolic pattern of the surrounding tissues; unique endothelial-derived factors that regulate organ development; and unique signal transduction mechanisms for precise regulation.
Comment on
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Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance.J Exp Med. 2022 Mar 7;219(3):e20210565. doi: 10.1084/jem.20210565. Epub 2022 Jan 20. J Exp Med. 2022. PMID: 35050301 Free PMC article.
