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. 2023 Jun;107(6):823-827.
doi: 10.1136/bjophthalmol-2021-320128. Epub 2022 Jan 27.

Intraocular pressure and diurnal fluctuation of open-angle glaucoma and ocular hypertension: a baseline report from the LiGHT China trial cohort

Yangfan Yang #  1 , Xinyi Zhang #  1 , Zidong Chen  1 , Yifan Wei  1 , Qiaona Ye  1 , Yanmei Fan  1 , Neil Nathwani  2 , Gus Gazzard  3   4 , Minbin Yu  5 ; LiGHT China Trial Study Group
Collaborators, Affiliations

Intraocular pressure and diurnal fluctuation of open-angle glaucoma and ocular hypertension: a baseline report from the LiGHT China trial cohort

Yangfan Yang et al. Br J Ophthalmol. 2023 Jun.

Abstract

Aims: To report the baseline intraocular pressure (IOP) characteristics and its diurnal fluctuation in the Laser in Glaucoma and Ocular Hypertension China cohort.

Methods: 622 primary open-angle glaucoma (POAG) patients and 149 ocular hypertension (OHT) patients were recruited at Zhongshan Ophthalmic Center from 2015 to 2019. Standardised ocular examinations were performed including IOP measurement using the Goldmann applanation tonometer. Daytime phasing IOP was recorded at 8:00, 10:00, 11:30, 14:30, 17:00 hour.

Results: The mean baseline IOP was 20.2 mm Hg for POAG patients and 24.4 mm Hg for OHT. Multiple regression analysis revealed that thicker central corneal thickness (CCT) was correlated with higher IOP in both POAG and OHT. Male gender and younger age were correlated with higher IOP only for POAG. As for diurnal IOP fluctuation, mean IOP fluctuation was 3.4 mm Hg in POAG eyes and 4.4 mm Hg in OHT. The peak and trough IOP occurred at 8:00 and 14:30 hour in both POAG and OHT eyes.

Conclusions: Younger age, male gender and thicker CCT are correlated to higher IOP in POAG patients while only thicker CCT is related to higher IOP in OHT patients. Peak IOP appears mostly at early morning or late afternoon and trough value occurs mostly at early afternoon.

Keywords: glaucoma; intraocular pressure.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Diurnal variation in intraocular pressure in POAG and OHT eyes. IOP intraocular pressure; OHT, ocular hypertension; POAG, primary open-angle glaucoma.
See this image and copyright information in PMC

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