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Case Reports
. 2021 Dec 31;11(2):142-145.
doi: 10.14581/jer.21021. eCollection 2021 Dec.

Cell-based Therapy Approach for Drug-resistant Epilepsy

Affiliations
Case Reports

Cell-based Therapy Approach for Drug-resistant Epilepsy

Pradeep V Mahajan et al. J Epilepsy Res. .

Abstract

Drug-resistant epilepsy (DRE) is a global public health problem. This category includes patients who continue to experience seizures despite long-term anti-epileptic medications. DRE can lead to severe disability and morbidity in older children and adults and is associated with increased risk of mortality than the general population. This report describes the case of a 15-year-old male patient with DRE successfully managed with autologous cell-based and hyperbaric oxygen therapy. The patient underwent two sessions of cell-based therapy consisting of cells derived from the bone marrow, adipose tissue, and peripheral blood followed by neuro-physiotherapy and oxygen therapy. Post-treatment, the patient experienced decrease in the frequency of seizures and reduction in the dosage of anti-epileptic medications. Electroencephalogram taken one year after the therapy revealed improvement in seizure activity. The outcomes in this case may be considered a preliminary finding in formulating more robust treatment strategies using cell-based therapy for DRE.

Keywords: Cellular therapy; Drug-resistant; Epilepsy.

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Conflict of interest statement

Conflict of interest The authors declare that they have no conflicts of interest to disclose.

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