Fibrinogen Longmont: A Clinically Heterogeneous Dysfibrinogenemia with Discrepant Fibrinogen Results Influenced by Clot Detection Method and Reagent

Becky Leung^{1

2}, Joanne Beggs¹, Jane Mason^{1

3

4}

Affiliations

¹ Department of Haematology, Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.
² School of Medicine, Griffith University, Gold Coast, Australia.
³ Queensland Hemophilia Centre, Royal Brisbane and Women's Hospital, Brisbane, Australia.
⁴ Faculty of Medicine, University of Queensland, Brisbane, Australia.

Becky Leung et al. TH Open. 2022.

. 2022 Jan 24;6(1):e18-e20.

doi: 10.1055/s-0041-1740644. eCollection 2022 Jan.

Becky Leung^{1

2}, Joanne Beggs¹, Jane Mason^{1

3

4}

¹ Department of Haematology, Pathology Queensland, Royal Brisbane and Women's Hospital, Brisbane, Australia.
² School of Medicine, Griffith University, Gold Coast, Australia.
³ Queensland Hemophilia Centre, Royal Brisbane and Women's Hospital, Brisbane, Australia.
⁴ Faculty of Medicine, University of Queensland, Brisbane, Australia.

No abstract available

Conflict of interest statement

Conflict of Interest None declared.

1. Subcommittee on Factor XIII and Fibrinogen . Casini A, Undas A, Palla R, Thachil J, de Moerloose P. Diagnosis and classification of congenital fibrinogen disorders: communication from the SSC of the ISTH. J Thromb Haemost. 2018;16(09):1887–1890. - PubMed
1. Casini A, Neerman-Arbez M, Ariëns R A, de Moerloose P. Dysfibrinogenemia: from molecular anomalies to clinical manifestations and management. J Thromb Haemost. 2015;13(06):909–919. - PubMed
1. Hill M, Dolan G. Diagnosis, clinical features and molecular assessment of the dysfibrinogenaemias. Haemophilia. 2008;14(05):889–897. - PubMed
1. Lefkowitz J B, DeBoom T, Weller A, Clarke S, Lavrinets D. Fibrinogen Longmont: a dysfibrinogenemia that causes prolonged clot-based test results only when using an optical detection method. Am J Hematol. 2000;63(03):149–155. - PubMed
1. Lounes K C, Lefkowitz J B, Coates A I, Hantgan R R, Henschen-Edman A, Lord S T. Fibrinogen Longmont. A heterozygous abnormal fibrinogen with B beta Arg-166 to Cys substitution associated with defective fibrin polymerization. Ann N Y Acad Sci. 2001;936:129–132. - PubMed