Core-Shell Fe3O4@Au Nanorod-Loaded Gels for Tunable and Anisotropic Magneto- and Photothermia

Abstract

Hyperthermia therapeutic treatments require improved multifunctional materials with tunable synergetic properties. Here, we report on the synthesis of Fe₃O₄@Au core-shell nanorods and their subsequent incorporation into an agarose hydrogel to obtain anisotropic magnetic and optical properties for magneto- and photothermal anisotropic transductions. Highly monodisperse ferrimagnetic Fe₃O₄ nanorods with tunable size were synthesized using a solvothermal method by varying the amount of hexadecylamine capping ligands. A gold shell was coated onto Fe₃O₄ nanorods by the intermediate formation of core-satellite structures and a subsequent controlled growth process, leading to an optical response variation from the visible to the near-infrared (NIR) region. The nanorods were oriented within an agarose hydrogel to fabricate free-standing anisotropic materials, providing a proof-of-concept for the applicability of these materials for anisotropic magneto- and photothermia applications. The strong gelling behavior upon cooling and shear-thinning behavior of agarose enable the fabrication of magnetically active continuous hydrogel filaments upon injection. These developed multifunctional nanohybrid materials represent a base for advanced sensing, biomedical, or actuator applications with an anisotropic response.

Keywords: agarose; anisotropy; core−shell; hydrogels; injectable; magnetic nanorods; magnetothermia; plasmonic.