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Review
. 2022 Jan 28;101(4):e28667.
doi: 10.1097/MD.0000000000028667.

MR imaging features of Lhermitte-Duclos disease: Case reports and literature review

Han-Wen Zhang  1 , Yuan-Qing Zhang  2 , Xiao-Lei Liu  1 , Yong-Qian Mo  1 , Yi Lei  1 , Fan Lin  1 , Yu-Ning Feng  1
Affiliations
Review

MR imaging features of Lhermitte-Duclos disease: Case reports and literature review

Han-Wen Zhang et al. Medicine (Baltimore). .

Abstract

Rationale: Lhermitte-Duclos disease (LDD) is a rare tumor of the nervous system with a typical "tiger striped'" sign, but its features on functional magnetic resonance imaging (fMRI) are still inconclusive.

Patient concerns: To explore the characteristics of LDDs using fMRI.

Diagnoses: We report 3 cases of pathologically confirmed LDDs.

Interventions: Three patients underwent brain tumor surgery.

Outcomes: All the patients had a good prognosis.

Lessons: Magnetic resonance spectroscopy and susceptibility-weighted imaging combined with conventional MRI can be used to better diagnose LDDs. Perfusion-weighted imaging is not specific for distinguishing cerebellar tumors. The combined application of fMRI and conventional MRI can improve the accuracy of LDD diagnoses.

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Conflict of interest statement

The authors have no conflicts of interests to disclose.

Figures

Figure 1
Figure 1
Schematic diagram of the pathology of Lhermitte-Duclos disease.
Figure 2
Figure 2
A 40-year-old female patient with intermittent headache. MR examination: A. T2-weighted imaging (orange arrow, tiger striped sign), B. T1-weighted imaging (orange arrow, tiger striped sign), C. enhanced MRI scan showed limited diffusion, D. enhanced MRI scan (orange arrow, vascular-like enhancement).
Figure 3
Figure 3
A 44-year-old female patient with occipital headache and unsteady gait. MR examination: A. T1-weighted imaging (orange arrow, tiger striped sign), B. T2-weighted imaging (orange arrow, tiger striped sign), C. Enhanced MRI scan (orange arrow, vascular-like enhancement), D. Perfusion-weighted imaging (increased local perfusion of the lesion).
Figure 4
Figure 4
Same patient as in Figure 3. MRS measurement chart.
Figure 5
Figure 5
A 37-year-old male patient with headache. A. T2-weighted imaging, B. T1-weighted imaging, C. Susceptibility-weighted imaging (orange arrow, the blood vessels between the brain lobes are clearly displayed), D. Enhanced MRI scan (orange arrow, vascular-like enhancement).
See this image and copyright information in PMC

References

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