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Multicenter Study
. 2022 Feb 24;109(3):274-282.
doi: 10.1093/bjs/znab443.

Wire- and magnetic-seed-guided localization of impalpable breast lesions: iBRA-NET localisation study

Rajiv V Dave  1 , Emma Barrett  2 , Jenna Morgan  3 , Mihir Chandarana  4 , Suzanne Elgammal  5 , Nicola Barnes  1 , Amtul Sami  4 , Tahir Masudi  6 , Sue Down  7 , Chris Holcombe  8 , Shelley Potter  9   10 , Santosh K Somasundaram  11 , Matthew Gardiner  12   13 , Senthurun Mylvaganam  14 , Anthony Maxwell  1   15 , James Harvey  1   16 ; iBRA-NET Localisation Study collaborative
Collaborators, Affiliations
Multicenter Study

Wire- and magnetic-seed-guided localization of impalpable breast lesions: iBRA-NET localisation study

Rajiv V Dave et al. Br J Surg. .

Abstract

Background: Wire localization is historically the most common method for guiding excision of non-palpable breast lesions, but there are limitations to the technique. Newer technologies such as magnetic seeds may allow some of these challenges to be overcome. The aim was to compare safety and effectiveness of wire and magnetic seed localization techniques.

Methods: Women undergoing standard wire or magnetic seed localization for non-palpable lesions between August 2018 and August 2020 were recruited prospectively to this IDEAL stage 2a/2b platform cohort study. The primary outcome was effectiveness defined as accurate localization and removal of the index lesion. Secondary endpoints included safety, specimen weight and reoperation rate for positive margins.

Results: Data were accrued from 2300 patients in 35 units; 2116 having unifocal, unilateral breast lesion localization. Identification of the index lesion in magnetic-seed-guided (946 patients) and wire-guided excisions (1170 patients) was 99.8 versus 99.1 per cent (P = 0.048). There was no difference in overall complication rate. For a subset of patients having a single lumpectomy only for lesions less than 50 mm (1746 patients), there was no difference in median closest margin (2 mm versus 2 mm, P = 0.342), re-excision rate (12 versus 13 per cent, P = 0.574) and specimen weight in relation to lesion size (0.15 g/mm2versus 0.138 g/mm2, P = 0.453).

Conclusion: Magnetic seed localization demonstrated similar safety and effectiveness to those of wire localization. This study has established a robust platform for the comparative evaluation of new localization devices.

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Figures

Fig 1
Fig 1
Flow chart of patients included in study NACT, received neoadjuvant chemotherapy
See this image and copyright information in PMC

References

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