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. 2022 Sep 29;75(6):953-958.
doi: 10.1093/cid/ciac052.

Surveillance for Disseminated Gonococcal Infections, Active Bacterial Core Surveillance (ABCs)-United States, 2015-2019

Emily J Weston  1 , Brooke L Heidenga  2 , Monica M Farley  3   4 , Amy Tunali  3   4 , Melissa Tobin D'Angelo  5 , Ashley Moore  5 , Kimberly Workowski  1   3 , Brian H Raphael  1 , Hillard Weinstock  1 , Elizabeth Torrone  1
Affiliations

Surveillance for Disseminated Gonococcal Infections, Active Bacterial Core Surveillance (ABCs)-United States, 2015-2019

Emily J Weston et al. Clin Infect Dis. .

Abstract

Background: Disseminated gonococcal infections (DGIs) are thought to be uncommon; surveillance is limited, and case reports are analyzed retrospectively or in case clusters. We describe the population-level burden of culture-confirmed DGIs through the Active Bacterial Core surveillance (ABCs) system.

Methods: During 2015-2016, retrospective surveillance was conducted among residents in 2 ABCs areas and prospectively in 3 ABCs areas during 2017-2019. A DGI case was defined as isolation of Neisseria gonorrhoeae from a normally sterile site. A case report form was completed for each case and antimicrobial susceptibility testing (AST) was performed on available isolates.

Results: During 2015-2019, 77 DGI cases were identified (a rate of 0.13 cases per 100 000 population) and accounted for 0.06% of all reported gonorrhea cases in the 3 surveillance areas. Most DGI cases were male (64%), non-Hispanic Black (68%), and ranged from 16 to 67 years of age; blood (55%) and joint (40%) were the most common sterile sites. Among 29 isolates with AST results during 2017-2019, all were susceptible to ceftriaxone.

Conclusions: DGI is an infrequent complication of N gonorrhoeae; because it can quickly develop antimicrobial resistance, continued DGI surveillance, including monitoring trends in antimicrobial susceptibility, could help inform DGI treatment recommendations.

Keywords: Neisseria gonorrhoeae; Active Bacterial Core surveillance (ABCs) system; disseminated gonococcal infections; gonorrhea.

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Conflict of interest statement

Potential conflicts of interest. M. M. F. reports a National Institutes of Health grant unrelated to this article outside of the conduct of the study. All other authors report no potential conflicts. All authors have submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest. Conflicts that the editors consider relevant to the content of the manuscript have been disclosed.

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