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. 2022 Jan;18(1):1-4.
doi: 10.1016/j.reumae.2020.06.007. Epub 2020 Oct 15.

Inflammatory response in relation to COVID-19 and other prothrombotic phenotypes

José A Páramo  1
Affiliations

Inflammatory response in relation to COVID-19 and other prothrombotic phenotypes

José A Páramo. Reumatol Clin (Engl Ed). 2022 Jan.

Abstract
in English, Spanish

The haemostatic system acts in concert with inflammation, so that after inflammatory response various mediators activate the haemostatic system through endothelial dysfunction, platelet activation and coagulation promoting thrombosis, which is termed thromboinflammation. In this process, the inflammasome acquires special relevance; its stimulation promotes innate and adaptive immune responses. Inflammasome activation plays an important physiopathological role in several disorders with inflammatory and thrombotic phenomena. The role of thromboinflammation has become relevant in the COVID-19 pandemic, in which a cytokine storm has been described as one of the mechanisms responsible.

El sistema hemostático actúa en concierto con la inflamación, de forma que tras la respuesta inflamatoria diversos mediadores activan el sistema hemostático a través de disfunción endotelial, activación plaquetar y de coagulación, promoviendo la trombosis, lo que se ha denominado tromboinflamación. En este proceso adquiere especial relevancia el inflamasoma, cuya estimulación promueve respuestas inmunes innata y adaptativa. La activación del inflamasoma juega un papel fisopatológico importante en diversas patologías que cursan con fenómenos inflamatorios y trombóticos. El papel de la tromboinflamación se ha puesto de relevancia en la pandemia por COVID-19, en la que se ha descrito una tormenta de citocinas como uno de los mecanismos responsables.

Keywords: Autoimmune diseases; Coagulación; Coagulation; Enfermedades autoinmunes; Inflamasoma; Inflammation; Thrombosis; Trombosis.

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Figures

Fig. 1
Fig. 1
Role of the inflammasome in relation to the prothrombotic phenotypes.
See this image and copyright information in PMC

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