Structural insights into MRGPRX2: A new vision of itch and allergy

Affiliations

¹ Division of Biology and Biomedical Sciences, Washington University School of Medicine, St Louis, Mo.
² Kimberly and Eric J. Waldman Department of Dermatology, Precision Immunology Institute, Friedman Brain Institute, Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: itchdoctor@mountsinai.org.

Editorial

Anna M Trier et al. J Allergy Clin Immunol. 2022 Apr.

. 2022 Apr;149(4):1221-1222.

doi: 10.1016/j.jaci.2022.01.017. Epub 2022 Jan 26.

¹ Division of Biology and Biomedical Sciences, Washington University School of Medicine, St Louis, Mo.
² Kimberly and Eric J. Waldman Department of Dermatology, Precision Immunology Institute, Friedman Brain Institute, Mark Lebwohl Center for Neuroinflammation and Sensation, Icahn School of Medicine at Mount Sinai, New York, NY. Electronic address: itchdoctor@mountsinai.org.

No abstract available

Keywords: Allergy; GPCR; MRGPRX2; MRGPRX4; Mrgprs; cryogenic electron microscopy; itch; pruritus; pseudoallergic.

Comment on

Structure, function and pharmacology of human itch GPCRs.
Cao C, Kang HJ, Singh I, Chen H, Zhang C, Ye W, Hayes BW, Liu J, Gumpper RH, Bender BJ, Slocum ST, Krumm BE, Lansu K, McCorvy JD, Kroeze WK, English JG, DiBerto JF, Olsen RHJ, Huang XP, Zhang S, Liu Y, Kim K, Karpiak J, Jan LY, Abraham SN, Jin J, Shoichet BK, Fay JF, Roth BL. Cao C, et al. Nature. 2021 Dec;600(7887):170-175. doi: 10.1038/s41586-021-04126-6. Epub 2021 Nov 17. Nature. 2021. PMID: 34789874 Free PMC article.
Structure, function and pharmacology of human itch receptor complexes.
Yang F, Guo L, Li Y, Wang G, Wang J, Zhang C, Fang GX, Chen X, Liu L, Yan X, Liu Q, Qu C, Xu Y, Xiao P, Zhu Z, Li Z, Zhou J, Yu X, Gao N, Sun JP. Yang F, et al. Nature. 2021 Dec;600(7887):164-169. doi: 10.1038/s41586-021-04077-y. Epub 2021 Nov 17. Nature. 2021. PMID: 34789875