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. 2022 Mar 1;44(2):40-42.
doi: 10.1097/MPH.0000000000002405.

Documented Viral Illness at the Time of Splenic Sequestration Does Not Affect the Odds of Recurrence in Children With Sickle Cell Disease

Omoyeni Clement  1 , Joanna Fishbein  2 , Abena Appiah-Kubi  3 , Banu Aygun  3
Affiliations

Documented Viral Illness at the Time of Splenic Sequestration Does Not Affect the Odds of Recurrence in Children With Sickle Cell Disease

Omoyeni Clement et al. J Pediatr Hematol Oncol. .

Abstract

This retrospective study investigates the relationship between the presence of a documented viral infection in children with sickle cell disease during their first splenic sequestration crisis and their odds of recurrence. Forty-eight children were admitted to our hospital between 2008 and 2018 with a splenic sequestration crisis. Thirty-six had respiratory viral panels done on admission, 13 of whom were positive. Two additional children were diagnosed with parvovirus B19 infection by serology. The recurrence rate was 52% (17/33) for those deemed negative for viral illness compared with 33% (5/15) among those with a positive documented viral illness, which was not statistically different (P=0.35). HbSC genotype decreased, and reticulocytosis increased the odds of recurrence. Further research is needed to substantiate these findings.

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Conflict of interest statement

The authors declare no conflict of interest.

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