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. 2022 Mar;51(3):102328.
doi: 10.1016/j.jogoh.2022.102328. Epub 2022 Jan 29.

Sickle cell disease and COVID-19 in pregnant women

Kamila Kolanska  1 , Radostina Vasileva  2 , François Lionnet  3 , Aline Santin  3 , Suha Jaudi  2 , Yohann Dabi  2 , Nathalie Chabbert-Buffet  2 , Emile Daraï  2 , Marie Bornes  2
Affiliations

Sickle cell disease and COVID-19 in pregnant women

Kamila Kolanska et al. J Gynecol Obstet Hum Reprod. 2022 Mar.

Abstract

Introduction: The effect of coronavirus disease (COVID-19) on pregnancy outcome in women with sickle cell disease (SCD) is unknown.

Objectives: To analyze the severity of the SARS-CoV-2 infection in pregnant women with SCD and its impact on pregnancy.

Methods: This retrospective cohort study included SCD pregnant women tested positive for COVID-19 between March 2020 - February 2021. The primary endpoint was the severity of the COVID-19 infection. Secondary endpoints were pregnancy complications and fetal outcomes.

Results: During the study period among 82 pregnant women with SCD, 8 have presented symptoms suggestive of COVID-19 and were tested positive. A common mild clinical presentation was observed in 6 women (75%), one woman was asymptomatic and one required oxygen. The latter was admitted to the Intensive Care Unit and a cesarean section was performed in the context of an ongoing vaso-occlusive crisis and acute chest syndrome together with incidental preeclampsia. Labor was induced in another patient who developed a vaso-occlusive crisis after COVID-19 remission. Fetal outcomes were good with an average Apgar score of 10 and normal umbilical blood pH at birth. Two newborns were small-for-gestational-age as expected on the ultrasound follow-up before occurrence of COVID-19.

Conclusion: COVID-19 infection in our population of pregnant women with SCD had typical presentation and rarely triggered a sickle cell crisis or other complications. Fetal outcomes were good and did not seem to be directly influenced by the SARS-CoV-2 virus. Further studies are required to confirm these observations as compared to the population of women with SCD without COVID-19 infection.

Keywords: COVID-19; Pregnancy complications; Sickle-cell disease.

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Conflict of interest statement

Declaration of Competing Interest This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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