Inhaled pulmonary vasodilators in severe COVID-19: Don't hold your breath

doi:10.1016/j.jcrc.2022.153988

Comment

. 2022 Jun:69:153988.

doi: 10.1016/j.jcrc.2022.153988. Epub 2022 Jan 28.

Inhaled pulmonary vasodilators in severe COVID-19: Don't hold your breath

Swapnil S Pawar¹, M Elizabeth Wilcox², Frank M P van Haren³

Affiliations

¹ Intensive Care Unit, St George Hospital, Sydney, Australia; University of New South Wales Medicine and Health, Sydney, Australia.
² Department of Medicine, Toronto Western Hospital, Toronto, Canada; Interdepartment Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
³ Intensive Care Unit, St George Hospital, Sydney, Australia; University of New South Wales Medicine and Health, Sydney, Australia; Australian National University, College of Health and Medicine, Canberra, Australia. Electronic address: fvanharen@me.com.

PMID: 35093675
PMCID: PMC8798495
DOI: 10.1016/j.jcrc.2022.153988

Comment

Inhaled pulmonary vasodilators in severe COVID-19: Don't hold your breath

Swapnil S Pawar et al. J Crit Care. 2022 Jun.

. 2022 Jun:69:153988.

doi: 10.1016/j.jcrc.2022.153988. Epub 2022 Jan 28.

Authors

Swapnil S Pawar¹, M Elizabeth Wilcox², Frank M P van Haren³

Affiliations

¹ Intensive Care Unit, St George Hospital, Sydney, Australia; University of New South Wales Medicine and Health, Sydney, Australia.
² Department of Medicine, Toronto Western Hospital, Toronto, Canada; Interdepartment Division of Critical Care Medicine, University of Toronto, Toronto, Canada.
³ Intensive Care Unit, St George Hospital, Sydney, Australia; University of New South Wales Medicine and Health, Sydney, Australia; Australian National University, College of Health and Medicine, Canberra, Australia. Electronic address: fvanharen@me.com.

PMID: 35093675
PMCID: PMC8798495
DOI: 10.1016/j.jcrc.2022.153988

No abstract available

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Conflict of interest statement

Declaration of Competing Interest All authors declare no conflict of interest. No funding was obtained for this work.

Comment on

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Use of Inhaled Epoprostenol in Patients With COVID-19 Receiving Humidified, High-Flow Nasal Oxygen Is Associated With Progressive Respiratory Failure.
Michelson AP, Lyons PG, Nguyen NM, Reynolds D, McDonald R, McEvoy CA, Despotovic V, Brody SL, Kollef MH, Kraft BD. Michelson AP, et al. CHEST Crit Care. 2023 Dec;1(3):100019. doi: 10.1016/j.chstcc.2023.100019. Epub 2023 Sep 25. CHEST Crit Care. 2023. PMID: 38516615 Free PMC article.
A Comparative Investigation of the Pulmonary Vasodilating Effects of Inhaled NO Gas Therapy and Inhalation of a New Drug Formulation Containing a NO Donor Metabolite (SIN-1A).
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References

1. Panwar R., Madotto F., Laffey J.G., Van Haren F.M.P., Investigators L.S., the ETG. Compliance phenotypes in early ARDS before the COVID-19 pandemic. Am J Respir Crit Care Med. 2020;202(9):1244–1252. - PMC - PubMed
1. Gattinoni L., Chiumello D., Caironi P., Busana M., Romitti F., Brazzi L., et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med. 2020;46:1099–1102. - PMC - PubMed
1. Marini J.J., Gattinoni L. Management of COVID-19 respiratory distress. JAMA. 2020;323:2329–2330. - PubMed
1. Li H., Liu S.M., Yu X.H., Tang S.L., Tang C.K. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents. 2020;55 - PMC - PubMed
1. Varga Z., Flammer A.J., Steiger P., Haberecker M., Andermatt R., Zinkernagel A.S., et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417–1418. - PMC - PubMed

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[1] Panwar R., Madotto F., Laffey J.G., Van Haren F.M.P., Investigators L.S., the ETG. Compliance phenotypes in early ARDS before the COVID-19 pandemic. Am J Respir Crit Care Med. 2020;202(9):1244–1252. - PMC - PubMed

[2] Panwar R., Madotto F., Laffey J.G., Van Haren F.M.P., Investigators L.S., the ETG. Compliance phenotypes in early ARDS before the COVID-19 pandemic. Am J Respir Crit Care Med. 2020;202(9):1244–1252. - PMC - PubMed

[3] Gattinoni L., Chiumello D., Caironi P., Busana M., Romitti F., Brazzi L., et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med. 2020;46:1099–1102. - PMC - PubMed

[4] Gattinoni L., Chiumello D., Caironi P., Busana M., Romitti F., Brazzi L., et al. COVID-19 pneumonia: different respiratory treatments for different phenotypes? Intensive Care Med. 2020;46:1099–1102. - PMC - PubMed

[5] Marini J.J., Gattinoni L. Management of COVID-19 respiratory distress. JAMA. 2020;323:2329–2330. - PubMed

[6] Marini J.J., Gattinoni L. Management of COVID-19 respiratory distress. JAMA. 2020;323:2329–2330. - PubMed

[7] Li H., Liu S.M., Yu X.H., Tang S.L., Tang C.K. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents. 2020;55 - PMC - PubMed

[8] Li H., Liu S.M., Yu X.H., Tang S.L., Tang C.K. Coronavirus disease 2019 (COVID-19): current status and future perspectives. Int J Antimicrob Agents. 2020;55 - PMC - PubMed

[9] Varga Z., Flammer A.J., Steiger P., Haberecker M., Andermatt R., Zinkernagel A.S., et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417–1418. - PMC - PubMed

[10] Varga Z., Flammer A.J., Steiger P., Haberecker M., Andermatt R., Zinkernagel A.S., et al. Endothelial cell infection and endotheliitis in COVID-19. Lancet. 2020;395:1417–1418. - PMC - PubMed

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Inhaled pulmonary vasodilators in severe COVID-19: Don't hold your breath

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Inhaled pulmonary vasodilators in severe COVID-19: Don't hold your breath

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