Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Multicenter Study
. 2022 Apr 1;41(4):e142-e145.
doi: 10.1097/INF.0000000000003476.

Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

Ulrikka Nygaard  1   2 , Andreas Petersen  3 , Anders Rhod Larsen  3 , Maren Johanne Heilskov Rytter  2   4 , Ulla Hartling  5 , Nikolai Kirkby  6 , Rikke Nymark Hansen  7 , Allan Bybeck Nielsen  1 , Kaare Lundstrøm  1 , Mette Holm  8 , Nadja Hawwa Vissing  1
Affiliations
Multicenter Study

Fatal SARS-CoV-2-Associated Panton-Valentine Leukocidin-producing Staphylococcal Bacteremia: A Nationwide Multicenter Cohort Study

Ulrikka Nygaard et al. Pediatr Infect Dis J. .

Abstract

We reviewed all cases of Panton-Valentine leukocidin-producing Staphylococcus aureus (PVL-SA) bacteremia in Danish children between 2016 and 2021. We found 2 fatal cases with preceding viral prodrome due to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the usual benign course of SARS-CoV-2 infection in children, awareness of possible superinfection with PVL-SA in a child with rapid deterioration is crucial to ensure adequate treatment, including antimicrobial drugs with antitoxin effect.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

References

    1. Kaneko J, Kamio Y. Bacterial two-component and hetero-heptameric pore-forming cytolytic toxins: structures, pore-forming mechanism, and organization of the genes. Biosci Biotechnol Biochem. 2004;68:981–1003.
    1. Diep BA, Chan L, Tattevin P, et al. Polymorphonuclear leukocytes mediate Staphylococcus aureus Panton-Valentine leukocidin-induced lung inflammation and injury. Proc Natl Acad Sci USA. 2010;107:5587–5592.
    1. Martínez-Aguilar G, Avalos-Mishaan A, Hulten K, et al. Community-acquired, methicillin-resistant and methicillin-susceptible Staphylococcus aureus musculoskeletal infections in children. Pediatr Infect Dis J. 2004;23:701–706.
    1. Hoppe PA, Holzhauer S, Lala B, et al. Severe infections of Panton-Valentine leukocidin positive Staphylococcus aureus in children. Medicine (Baltimore). 2019;98:e17185.
    1. Bybeck Nielsen A, Larsen AR, Petersen A, et al. Clinical manifestations in children with staphylococcal bacteremia positive for panton-valentine leucocidin: a nationwide survey in a low methicillin-resistance setting. Pediatr Infect Dis J. 2020;39:e274–e276.

Publication types

MeSH terms