Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Jul;279(7):3511-3517.
doi: 10.1007/s00405-022-07276-z. Epub 2022 Jan 30.

The effect of locally administered phenytoin on wound healing in an experimental nasal septal perforation animal model

Doğan Çakan  1 , Semih Uşaklıoğlu  2
Affiliations

The effect of locally administered phenytoin on wound healing in an experimental nasal septal perforation animal model

Doğan Çakan et al. Eur Arch Otorhinolaryngol. 2022 Jul.

Abstract

Purpose: In the present study, we aimed to investigate the effect of phenytoin (PHT) on wound healing in an experimental nasal septal perforation (NSP) model created in rats.

Methods: Twenty-two Sprague Dawley male rats were randomized into two groups. NSP, approximately 2 mm in diameter, was created in each subject. The 1% PHT cream (Study group) and saline (Control group) were applied topically once a day for 14 days. The subjects were sacrificed at the end of 14th day and the nasal septum of each animal was excised for histopathological examination. The epithelial regeneration and degeneration of the nasal mucosa, acute inflammatory cells number, fibroblast number, collagen density, vascularization, eosinophil number, granulation tissue formation, giant cell number, degeneration and regeneration of the nasal cartilage were examined. The macroscopic closure rate of NPSs and histopathological parameters were analyzed statistically.

Results: In this study, the epithelial regeneration, the fibroblast count, the collagen density, the vascularization and the amount of granulation tissue and the macroscopic clouse rate of NSPs were significantly higher in the PHT group than in the saline group (p < .05). There was no significant difference was in other comparisons (p > .05).

Conclusion: The locally administered phenytoin may accelerate wound healing of nasal septum in an experimental NSP model. Consequently, phenytoin might be used as an effective substance to prevent the formation of NSP.

Keywords: Experimental study; Nasal septal perforation; Nasal septum; Phenytoin; Wound healing.

PubMed Disclaimer

References

    1. Robson MC, Steed DL, Franz MG (2001) Wound healing: biologic features and approaches to maximize healing trajectories. Curr Probl Surg 38:72–140 - PubMed
    1. Lindley LE, Stojadinovic O, Pastar I, Tomic-Canic M (2016) Biology and biomarkers for wound healing. Plast Reconstr Surg 138(3 Suppl):18–28
    1. Wang PH, Huang BS, Horng HC, Yeh CC, Chen YJ (2018) Wound healing. J Chin Med Assoc 81(2):94–101 - PubMed
    1. Alobid I (2019) Endoscopic approach for management of septal perforation. Eur Arch Otorhinolaryngol 276(8):2115–2123 - PubMed
    1. Gold M, Boyack I, Caputo N, Pearlman A (2017) Imaging prevalence of nasal septal perforation in an urban population. Clin Imaging 20(43):80–82

LinkOut - more resources