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. 2022 Apr 1;68(2):144-151.
doi: 10.1262/jrd.2021-120. Epub 2022 Jan 28.

Effects of heat stress on the endometrial epidermal growth factor profile and fertility in dairy cows

Kohei Kawano  1 , Yojiro Yanagawa  2 , Masashi Nagano  2   3 , Seiji Katagiri  2
Affiliations

Effects of heat stress on the endometrial epidermal growth factor profile and fertility in dairy cows

Kohei Kawano et al. J Reprod Dev. .

Abstract

The endometrial epidermal growth factor (EGF) profile is an indicator of uterine function and fertility in cattle. The present study aimed to investigate the effects of heat stress on the endometrial EGF profile and fertility in lactating Holstein cows. The endometrial EGF profiles of 365 cows in the Hokkaido and Kyushu regions were examined between June and September (heat stress period, n = 211) and between October and January (control period, n = 154). EGF profiles were investigated using uterine endometrial tissues obtained by biopsy 3 days after estrus (Day 3). The proportion of cows with an altered EGF profile was higher between June and September than between October and January (41.2 vs. 16.2%, P < 0.05). The effects of rectal temperature on Days 0 and 3 on the endometrial EGF profile were also assessed in cows (n = 79) between June and September in the Kyushu region. A single embryo was transferred to cow on Day 7 to evaluate fertility (n = 67). Regardless of the rectal temperature on Day 3, the proportion of cows with an altered EGF profile was higher (64.1 vs. 30.0%, P < 0.05) and the pregnancy rate after embryo transfer (ET) was lower (26.7 vs. 51.4%, P < 0.05) in cows with a rectal temperature ≥ 39.5°C on Day 0 than in cows with a rectal temperature < 39.5°C on Day 0. The present results indicate that alterations in the endometrial EGF profile induced by an elevated body temperature on Day 0 contributed to reductions in fertility in lactating dairy cows during the heat stress period.

Keywords: Dairy cow; Embryo transfer; Endometrial epidermal growth factor; Heat stress.

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Conflict of interest statement

The authors declare that there is no conflict of interests.

Figures

Fig. 1.
Fig. 1.
Mean monthly temperature humidity index (THI) of the study period (2015–2017) in two regions (Hokkaido: Sapporo Δ and Tomakomai □; Kyushu: Fukuoka ♦ and Kumamoto ●).
See this image and copyright information in PMC

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