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. 2022 Jan 13:12:754406.
doi: 10.3389/fendo.2021.754406. eCollection 2021.

Maternal Pre-Pregnancy Obesity Combined With Abnormal Glucose Metabolism Further Increases Adverse Pregnancy Outcomes in Chinese Pregnant Women

Mei-Fang Li  1   2 , Jiang-Feng Ke  1 , Li Ma  3 , Jun-Wei Wang  1 , Zhi-Hui Zhang  1 , Jing-Bo Li  4 , Lian-Xi Li  1
Affiliations

Maternal Pre-Pregnancy Obesity Combined With Abnormal Glucose Metabolism Further Increases Adverse Pregnancy Outcomes in Chinese Pregnant Women

Mei-Fang Li et al. Front Endocrinol (Lausanne). .

Abstract

Aims: Our aim was to evaluate the separate and combined effects of maternal pre-pregnancy obesity and gestational abnormal glucose metabolism (GAGM) on adverse perinatal outcomes.

Methods: A total of 2,796 Chinese pregnant women with singleton delivery were studied, including 257 women with pre-pregnancy obesity alone, 604 with GAGM alone, 190 with both two conditions, and 1,745 with neither pre-pregnancy obesity nor GAGM as control group. The prevalence and risks of adverse pregnancy outcomes were compared among the four groups.

Results: Compared with the normal group, pregnant women with maternal pre-pregnancy obesity alone, GAGM alone, and both two conditions faced significantly increased risks of pregnancy-induced hypertension (PIH) (odds ratio (OR) 4.045, [95% confidence interval (CI) 2.286-7.156]; 1.993 [1.171-3.393]; 8.495 [4.982-14.485]), preeclampsia (2.649 [1.224-5.735]; 2.129 [1.128-4.017]; 4.643 [2.217-9.727]), cesarean delivery (1.589 [1.212-2.083]; 1.328 [1.095-1.611]; 2.627 [1.908-3.617]), preterm delivery (1.899 [1.205-2.993]; 1.358 [0.937-1.968]; 2.301 [1.423-3.720]), macrosomia (2.449 [1.517-3.954]; 1.966 [1.356-2.851]; 4.576 [2.895-7.233]), and total adverse maternal outcomes (1.762 [1.331-2.332]; 1.365 [1.122-1.659]; 3.228 [2.272-4.587]) and neonatal outcomes (1.951 [1.361-2.798]; 1.547 [1.170-2.046]; 3.557 [2.471-5.122]). Most importantly, there were no obvious risk differences in adverse pregnancy outcomes between maternal pre-pregnancy obesity and GAGM group except PIH, but pregnant women with both obesity and GAGM exhibited dramatically higher risks of adverse pregnancy outcomes than those with each condition alone.

Conclusions: Maternal pre-pregnancy obesity and GAGM were independently associated with increased risks of adverse pregnancy outcomes. The combination of pre-pregnancy obesity and GAGM further worsens adverse pregnancy outcomes compared with each condition alone.

Keywords: adverse pregnancy outcomes; gestational abnormal glucose metabolism; gestational diabetes mellitus; pre-pregnancy obesity; women of reproductive age.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Comparison of adverse maternal outcomes between pre-pregnancy obesity alone and GAGM alone. Adjusted: adjusted for maternal age, gestational age, and primiparity. Adjusteda: adjusted for maternal age, and primiparity.
Figure 2
Figure 2
Comparison of adverse neonatal outcomes between pre-pregnancy obesity alone and GAGM alone. Adjusted: adjusted for maternal age, gestational age, and primiparity. Adjusteda: adjusted for maternal age, and primiparity.
See this image and copyright information in PMC

References

    1. Catalano PM, Hauguel-De Mouzon S. Is it Time to Revisit the Pedersen Hypothesis in the Face of the Obesity Epidemic? Am J Obstet Gynecol (2011) 204(6):479–87. doi: 10.1016/j.ajog.2010.11.039 - DOI - PMC - PubMed
    1. Charles MA, Eschwège E, Basdevant A. Monitoring the Obesity Epidemic in France: The Obepi Surveys 1997-2006. Obes (Silver Spring) (2008) 16(9):2182–6. doi: 10.1038/oby.2008.285 - DOI - PMC - PubMed
    1. Li HT, Xue M, Hellerstein S, Cai Y, Gao Y, Zhang Y, et al. . Association of China's Universal Two Child Policy With Changes in Births and Birth Related Health Factors: National, Descriptive Comparative Study. BMJ (2019) 366:l4680. doi: 10.1136/bmj.l4680 - DOI - PMC - PubMed
    1. Liu X, Huang D, Wang Y, Gao Y, Chen M, Bai Y, et al. . Birth and Birth-Related Obstetrical Characteristics in Southwestern China Associated With the Current Adjustment of Family Planning Policy: A 7-Year Retrospective Study. Sci Rep (2020) 10(1):15949. doi: 10.1038/s41598-020-73039-7 - DOI - PMC - PubMed
    1. Owens LA, O'Sullivan EP, Kirwan B, Avalos G, Gaffney G, Dunne F, et al. . ATLANTIC DIP: The Impact of Obesity on Pregnancy Outcome in Glucose-Tolerant Women. Diabetes Care (2010) 33(3):577–9. doi: 10.2337/dc09-0911 - DOI - PMC - PubMed

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