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Review
. 2021 Mar 29;26(1):e158-e166.
doi: 10.1055/s-0040-1722250. eCollection 2022 Jan.

The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Natalia Ferrazoli  1   2 , Caroline Donadon  2   3 , Adriano Rezende  2 , Piotr H Skarzynski  4   5 , Milaine Dominici Sanfins  2   6
Affiliations
Review

The Application of P300-Long-Latency Auditory-Evoked Potential in Parkinson Disease

Natalia Ferrazoli et al. Int Arch Otorhinolaryngol. .

Abstract

Introduction Parkinson disease (PD) is a degenerative and progressive neurological disorder characterized by resting tremor, stiffness, bradykinesia, and postural instability. Despite the motor symptoms, PD patients also consistently show cognitive impairment or executive dysfunction. The auditory event-related potential P300 has been described as the best indicator of mental function, being highly dependent on cognitive skills, including attention and discrimination. Objective To review the literature on the application and findings of P300 as an indicator of PD. Data Analysis The samples ranged from 7 to 166 individuals. Young adult and elderly male patients composed most study samples. The Mini-Mental State Examination test, the Unified Parkinson Disease Rating Scale, and the Hoehn and Yahr Scale were used to assess neurological and cognitive function. In terms of testing hearing function, few studies have focused on parameters other than the P300. The factors we focused on were how the P300 was modified by cognitive effects, its correlation with different PD scales, the effect of performing dual tasks, the effect of fatigue, and the influence of drug treatments. Conclusion The use of the P300 appears to be an effective assessment tool in patients with PD. This event-related potential seems to correlate well with other neurocognitive tests that measure key features of the disease.

Keywords: P300; Parkinson disease; attention; elderly; event-related potential.

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Conflict of interest statement

Conflict of Interests The authors have no conflict of interests to declare.

Figures

Fig. 1
Fig. 1
Flowchart of the selection of the studies.
See this image and copyright information in PMC

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