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. 2021 Oct 31;76(4):1069-1076.
doi: 10.22092/ari.2021.356047.1766. eCollection 2021 Oct.

Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly

N I Zhernakova  1 , S S Bunova  1 , N M Agarkov  1 , D T Lebedev  1 , V V Aksenov  2
Affiliations

Vitamin D Deficiency as an Independent Predictor of Myocardial Infarction in the Elderly

N I Zhernakova et al. Arch Razi Inst. .

Abstract

Cardiovascular diseases are among the most common causes of disability and death in the world, and the number of patients with this category of diseases is increasing every year. This study aimed to investigate the role of vitamin D and the problems caused by its deficiency on the cardiovascular system. Level of D-(25(OH]D) in blood was studied by enzyme immunoassay in 95 elderly patients with myocardial infarction (MI) (the main group) and 92 elderly patients with no history of MI. The level of lipid metabolism as an indicator was determined using a KoneLab 300 auto-analyzer. Based on the results of this study, it was found that the elderly group without MI had the highest amount of D-(25(OH]D)(24.5±1.2), compared to the elderly group with MI (14.8±1.3). The rates of expressed deficiency, deficiency, and insufficiency in the group of elderly with MI were 53.6±5.1, 23.2±4.4, and 12.6±3.4%, respectively. This experiment has shown that D-(25(OH]D) is involved in lipid metabolism and reduces the accumulation of cholesterol by macrophages. The content of vitamin D in blood plasma was a prognostic predictor of MI, which improved MI in the elderly. Regardless of pathological changes, the deficit level of D-(25(OH]D) should be considered a laboratory predictor of MI in the elderly.

Keywords: Lipid metabolism; Myocardial infarction; Old age Prognostic value; Vitamin D.

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References

    1. Hastings KG, Boothroyd DB, Kapphahn K, Hu J, Rehkopf DH, Cullen MR, et al. Socioeconomic differences in the epidemiologic transition from heart disease to cancer as the leading cause of death in the United States, 2003 to 2015: an observational study. Ann Intern Med. 2018;169(12):836–44. - PubMed
    1. Huang J, Wang Z, Hu Z, Jiang W, Li B. Association between blood vitamin D and myocardial infarction: A meta-analysis including observational studies. Clinica Chimica Acta. 2017;471:270–5. - PubMed
    1. Agarkov N, Markelov M, Markelova E, Lutai Y, Volkov P. The information content and predictive value of cardiac markers in myocardial infarction in the elderly. Adv. Gerontol 2020;33(1):82–6. - PubMed
    1. Hadaegh F, Harati H, Ghanbarian A, Azizi F. Prevalence of coronary heart disease among Tehran adults: Tehran Lipid and Glucose Study. East Mediterr Health J. 2009;15(1):157–66. - PubMed
    1. Kinosian B, Glick H, Garland G. Cholesterol and coronary heart disease: predicting risks by levels and ratios. Ann Intern Med. 1994;121(9):641–7. - PubMed