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Review
. 2022 Jan 18;12(1):1-7.
doi: 10.5500/wjt.v12.i1.1.

Human pegivirus infection after transplant: Is there an impact?

Anna Mrzljak  1 , Bojana Simunov  2 , Ivan Balen  3 , Zeljka Jurekovic  2 , Tatjana Vilibic-Cavlek  4
Affiliations
Review

Human pegivirus infection after transplant: Is there an impact?

Anna Mrzljak et al. World J Transplant. .

Abstract

The microbiome's role in transplantation has received growing interest, but the role of virome remains understudied. Pegiviruses are single-stranded positive-sense RNA viruses, historically associated with liver disease, but their path-ogenicity is controversial. In the transplantation setting, pegivirus infection does not seem to have a negative impact on the outcomes of solid-organ and hematopoietic stem cell transplant recipients. However, the role of pegiviruses as proxies in immunosuppression monitoring brings novelty to the field of virome research in immunocompromised individuals. The possible immunomodulatory effect of pegivirus infections remains to be elucidated in further trials.

Keywords: Epidemiology; Hematopoietic stem cell transplantation; Human pegivirus; Solid-organ transplant; Virome.

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Conflict of interest statement

Conflict-of-interest statement: The authors declare no conflict of interest for this article.

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