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Review
. 2022 Jan 13:12:e2021352.
doi: 10.4322/acr.2021.352. eCollection 2022.

Solid papillary carcinoma of the breast

Toyaja Jadhav  1 , Shashi Shekhar Prasad  1 , Bhupesh Guleria  2 , Manvir Singh Tevatia  3 , Prerna Guleria  1
Affiliations
Review

Solid papillary carcinoma of the breast

Toyaja Jadhav et al. Autops Case Rep. .

Abstract

Solid Papillary Carcinoma (SPC) of the breast is a rare tumor with an incidence of less than 1%, mainly affecting elderly females. It is morphologically characterized by well-defined nodules with low-grade nuclear features associated with fibrovascular cores and shows neuroendocrine differentiation. SPC can be in-situ or invasive but has a favorable prognosis. It is a morphological mimicker of some pre-malignant conditions leading to its frequent misdiagnosis. An appropriate immunohistochemical (IHC) panel workup helps in distinguishing this tumor from its various morphological mimics. In this report, we present one such case of SPC with a small focus of invasion, reviewing the literature.

Keywords: Breast Neoplasms; Carcinoma; Carcinoma, Papillary; Unilateral Breast Neoplasms.

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Conflict of interest statement

Conflict of interest: The authors declare that there is no conflict of interest.

Figures

Figure 1
Figure 1. FDG-PET scan shows an ill-defined, hypermetabolic, heterogeneously enhancing FDG avid soft tissue nodular lesion involving upper inner quadrant of the left breast in axial view (Figure 1A) and parasagittal view (Figure 1B).
Figure 2
Figure 2. Photomicrograph of the tumor. A – reveal a tumor arranged in circumscribed large cellular nodules, closely apposed and expanded, separated by bands of fibrovascular stroma. The tumor cells are round to oval with moderate pleomorphism with a central vascular core (H&E, 400X); B – Shows foci of stromal invasion (H&E, 100X).
Figure 3
Figure 3. Photomicrographs of the tumor. Immunohistochemical panel. A – Strong immunoreactivity for cytokeratin (CK7, 40x); B – positivity to Synaptophysin (100x); C – positivity to chromogranin (40x); D – E-cadherin retained within the tumor cells (40x).
Figure 4
Figure 4. Photomicrographs of the tumor. Immunohistochemical panel. A – CD34 highlights the intermixed blood vessels within the tumor (40x); B – p63 shows focal loss of myoepithelial cells along the invasive foci (40x); C and D – Breast biomarker studies reveal immunopositivity for Estrogen Receptor (ER) (Allred score 8/8) and Progesterone Receptor (PR) (Allred score 8/8) respectively (40x).
Figure 5
Figure 5. Photomicrographs of the tumor. Low to moderate Ki67 proliferation index of the tumor with 15-20% reactivity (40x).
See this image and copyright information in PMC

References

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