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. 2021 Dec 29;11(4):523-535.
doi: 10.18683/germs.2021.1287. eCollection 2021 Dec.

Antimicrobial use among hospitalized patients: A multi-center, point prevalence survey across public healthcare facilities, Osun State, Nigeria

Aaron O Aboderin  1 , Adeyemi T Adeyemo  2 , Ademola A Olayinka  3 , Adeniyi S Oginni  4 , Abolaji T Adeyemo  5 , Abayomi A Oni  6 , Olatunde F Olabisi  7 , Oluwaseun D Fayomi  8 , Anthony C Anuforo  9 , Abiodun Egwuenu  10 , Omotayo Hamzat  11 , Walter Fuller  12
Affiliations

Antimicrobial use among hospitalized patients: A multi-center, point prevalence survey across public healthcare facilities, Osun State, Nigeria

Aaron O Aboderin et al. Germs. .

Abstract

Introduction: In order to inform sub-national action plan for control of antimicrobial resistance (AMR) and benchmark interventions to improve antibiotic use, it is essential to define situations on antibiotic use using standardized tools. We sought to assess quality of antimicrobial prescription across all government healthcare facilities with capacities for in-patient care in the first of the 36 states in Nigeria as part of ongoing state-wide situation analysis on AMR.

Methods: A survey was conducted between 10-27 June 2019 using the WHO methodology for point prevalence survey on antibiotic use in hospitals. Data was collected from hospital administrators and records of hospitalized patients. Data analysis was done using Microsoft Excel 2010 (Redmond Washington).

Results: Prevalence of antibiotic use amongst all 321 included patients was 76.6% (246/321). Of all indications recorded, the highest was surgical prophylaxis (96/260, 36.9%) for which there were multiple doses beyond 24 hours in almost all cases (91/96, 94.8%). The largest volume of prescribing took place in the surgical wards, and the most common prescriptions were metronidazole (142/564, 25.2%), cefuroxime (104/564, 18.4%), and ceftriaxone (77/564, 13.7%). Overall, 46.3% of the antibiotics used belong to Access group, 53.5% to watch and only 0.2% to Reserve. Treatment in almost all instances 544/563 (96.6%) was empiric.

Conclusions: The majority of patients received multiple antibiotics mostly without compliance to guidelines. There was low prescribing of Access antibiotics and excessive use of antibiotics in the Watch group. Antibiotics were used most commonly for surgical prophylaxis but inappropriately. Inappropriate use of antibiotics in this study underscores the crucial need for an action plan incorporating antimicrobial stewardship.

Keywords: Antimicrobial; Osun state; prescribing; stewardship.

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Conflict of interest statement

Conflicts of interest: All authors – none to declare.

References

    1. O'Neill J. Review on Antimicrobial Resistance. London: 2014. Review on antimicrobial resistance antimicrobial resistance: tackling a crisis for the health and wealth of nations. Available at: https://amr-review.org/sites/default/files/AMR%20Review%20Paper%20-%20Ta....
    1. Resolution WHA 68-7. Geneva: World Health Organization; 2015. Global action plan on antimicrobial resistance. Sixty-eighth World Health Assembly, Geneva, 26 May 2015. Annex 3.
    1. A/RES/71/3. New York: United Nations; 2016. Political declaration of the high-level meeting of the General Assembly on antimicrobial resistance.
    1. National Action Plan for Antimicrobial Resistance (2017-2022) [Accessed on: 04 December 2020]. Available at: http://ncdc.gov.ng/themes/common/docs/protocols/77_1511368219.pdf.
    1. Geneva: World Health Organization; 2019. Antimicrobial stewardship programmes in health-care facilities in low- and middle-income countries. A practical toolkit. - PMC - PubMed

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