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. 2022 Jan 19:2022:5818840.
doi: 10.1155/2022/5818840. eCollection 2022.

Role of Salivary Biomarkers in Cystic Fibrosis: A Systematic Review

Asma Almeslet  1 , Sarah Alnamlah  2 , Latifa Alanzan  3 , Rawan Aldriwesh  4 , Sha'eah AlWehaiby  5
Affiliations

Role of Salivary Biomarkers in Cystic Fibrosis: A Systematic Review

Asma Almeslet et al. Biomed Res Int. .

Abstract

Background: Saliva biomarkers could be easily used as a noninvasive alternative tool for diagnosing cystic fibrosis (CF) disease. In this study, the significance of changes in salivary compositions in patients with CF was systematically reviewed.

Methods: An electronic search was utilized to include studies published in English, with case-control, cohort, or cross-sectional design. The evaluated salivary components were extracted and summarized. The included studies were assessed using the Strengthening the Reporting of Observational Studies in Epidemiology checklist.

Results: Out of 498 identified studies, nine met the eligibility criteria. Salivary electrolytes showed a substantial alteration in the CF group, especially with chloride and sodium. Total protein concentration was higher in patients with CF. However, SCN- concentration was lower in patients with CF. In addition, a reduction in the salivary flow rate and amylase levels was found in patients with CF.

Conclusion: Alterations in salivary biomarkers among patients with CF could be used as a promising diagnostic tool for cystic fibrosis.

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Conflict of interest statement

The authors declare no conflict of interests.

Figures

Figure 1
Figure 1
PRISMA flowchart of the study selection process.
See this image and copyright information in PMC

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