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Review
. 2022 Apr;237(4):2064-2077.
doi: 10.1002/jcp.30688. Epub 2022 Jan 30.

Adenosine diphosphate ribose cyclase: An important regulator of human pathological and physiological processes

Feng Zeng  1   2   3 , Ling Zhu  4 , Qianjin Liao  3 , Xin Li  5 , Yanhong Zhou  1   2   3
Affiliations
Review

Adenosine diphosphate ribose cyclase: An important regulator of human pathological and physiological processes

Feng Zeng et al. J Cell Physiol. 2022 Apr.

Abstract

Adenosine diphosphate ribose cyclase (ADPRC) exists widely in eukaryotes and lower metazoans cells. It can degrade nicotinamide adenine dinucleotide (NAD) into cyclic ADP ribose (cADPR) and nicotinamide, and subsequently hydrolyses cADPR to ADP ribose (ADPR). In this paper, we have summarized the relative subcellular localization of ADPRC and enzymes with ADPRC activity in organisms, related enzyme family members of ADPRC are also described. In addition, we discussed the main biological functions of ADPRC, the regulation of Ca2+ signal, the regulation of insulin and glucagon secretion, oxytocin secretion, and the effects of renal and pulmonary vasomotor tension. Finally, we expounded the relationship between ADPRC and human health and disease occurrence. It provides a theoretical basis for the targeted treatment of ADPRC as a pharmacological tool for related diseases, and has important significance in clinical diagnosis and disease intervention.

Keywords: ADPR cyclase; cell signaling; pathology; physiology; signal transduction pathways.

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References

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