Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;18(6):678-685.
doi: 10.1111/ajco.13749. Epub 2022 Jan 30.

Molecular characteristics of young-onset colorectal cancer in Vietnamese patients

Minh Duc Do  1 , Thinh Huu Nguyen  2 , Khuong Thai Le  1 , Linh Hoang Gia Le  1 , Bac Hoang Nguyen  2 , Kien Trung Le  2 , Thao Phuong Thi Doan  3 , Chuong Quoc Ho  1 , Hoai-Nghia Nguyen  1 , Tuan Diep Tran  3 , Hoang Anh Vu  1
Affiliations

Molecular characteristics of young-onset colorectal cancer in Vietnamese patients

Minh Duc Do et al. Asia Pac J Clin Oncol. 2022 Dec.

Abstract

Background: Colorectal cancer (CRC) is one of the most common cancer globally. Understanding the genetic characteristics of CRC is essential for appropriate treatment and genetic counseling.

Methods: The genetic profile of CRC tumor tissues was identified using next-generation sequencing of 17 target genes (MLH1, MSH2, MSH6, PMS2, EPCAM, APC, SMAD4, BMPR1A, MUTYH, STK11, PTEN, TP53, ATM, CDH1, CHEK2, POLE, and POLD1) in a cohort of 101 Vietnamese patients diagnosed with young-onset CRC. Corresponding germline genetic alterations of determined somatic mutations were subsequently confirmed from patients' blood samples.

Results: Somatic mutations were determined in 96 out of 101 CRC patients. Two-thirds of the tumors harbored more than two mutations, and the most prevalent mutated genes were TP53 and APC. Among confirmed germline mutations, 10 pathogenic mutations and 11 variants of unknown significance were identified.

Conclusions: Given the burden of CRC and the gradually reducing cost of genetic testing, multigene panel screening can benefit young-onset CRC patients as well as their relatives.

Keywords: germline mutation; next-generation sequencing; somatic mutation; young-onset colorectal cancer.

PubMed Disclaimer

References

REFERENCES

    1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: gLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018;68(6):394-424. Nov.
    1. Siegel RL, Miller KD, Goding Sauer A et al. Colorectal cancer statistics, 2020. CA Cancer J Clin. 2020;70(3):145-164.
    1. Vuik FE, Nieuwenburg SA, Bardou M et al. Increasing incidence of colorectal cancer in young adults in Europe over the last 25 years. Gut. 2019;68(10):1820-1826. Oct.
    1. Saad El Din K, Loree JM, Sayre EC, Gill S et al. Trends in the epidemiology of young-onset colorectal cancer: A worldwide systematic review. BMC Cancer. 2020;20(1):288. Apr 6.
    1. Wolf AMD, Fontham ETH, Church TR et al. Colorectal cancer screening for average-risk adults: 2018 guideline update from the American Cancer Society. CA Cancer J Clin. 2018;68(4):250-281. Jul.